Actions for Near-term and late biological effects of acute and low-dose-rate continuous gamma-ray exposure in dogs and monkeys [electronic resource].

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Near-term and late biological effects of acute and low-dose-rate continuous gamma-ray exposure in dogs and monkeys [electronic resource].

Published
Los Alamos, N.M. : Los Alamos Scientific Laboratory, 1979.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
Pages: 11 : digital, PDF file
Additional Creators
Los Alamos Scientific Laboratory and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Monkeys (Macaca mulatta) and dogs (beagle) were given thirteen 100-rad gamma-ray doses at 28-day intervals. The comparative response (inury and recovery) of the hematopoietic system of the two species was observed at 7-day intervals during the exposure regime. At 84 days after the thirteenth gamma-ray dose, the 1300-rad conditioned and control dogs and monkeys were challenged continuously with gamma rays at 35 r/day until death to determine the amount of radiation-induced injry remaining in conditioned animals as a reduction in mean survival time. Dogs (50%) and monkeys (8%) died from injury incurred during conditioning exposures. Thus, the comparative response (in terms of lethality) of dogs and monkeys to dose protraction by acute dose fractionation was similar to what we would expect from a single acute dose. The mean survival times for nonconditioned dogs and monkeys during continuous exposure at 35 R/day were the same (approx. 1400 h). Thus, the hematopoietic response of the two species by this method of dose protraction was not significantly different. Mean survival times of conditioned dogs and monkeys during the continuous 35-R/day gamma-ray challenge exposure were greater (significant in dogs but not in monkeys) than for their control counterparts. Thus, long-term radiation-induced injury was not measurable by this method. Conditioning doses of more than 4 times the acute LD/sub 50//sup 30/ in dogs and approximately 2 times that in monkeys served only to increase both mean survival time and variance in a gamma-ray stress environment with a dose rate of 35 Rat/day.
Report Numbers
E 1.99:la-7947-ms
la-7947-ms
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Other Subject(s)
Note
Published through SciTech Connect.
07/01/1979.
"la-7947-ms"
Spalding, J.F.; Holland, L.M.
Funding Information
W-7405-ENG-36
View MARC record | catkey: 14794452