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Pathogenic mechanism in lung fibrosis. [Synergistic effects of BHT, O/sub 2/, and x rays in mice] [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 1979.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
Pages: 22 : digital, PDF file
Additional Creators
Oak Ridge National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
The purpose of the study was to examine whether an interaction between two agents causing alveolar epithelial damage would produce lung fibrosis. In mouse lung, intraperitoneal injection of the antioxidant butylated hydroxytoluene causes diffuse alveolar type I cell necrosis, followed by proliferation of type II alveolar cells. In animals exposed to 70% O/sub 2/ or 100-200 rad x rays during the phase of type II cell proliferation following BHT, diffuse interstitial lung fibrosis developed within 2 weeks. Quantitative analysis of the lungs for hydroxyproline showed that the interaction between BHT and O/sub 2/ or x rays was synergistic. If exposure to O/sub 2/ or x rays was delayed until epithelial recovery was complete, no fibrosis was seen. Abnormally high levels of lung collagen persisted up to 6 months after one single treatment with BHT and 100 rad x rays. A commonly seen form of chronic lung damage may thus be caused by an acute interaction between a bloodborne agent which damages the alveolar cell and a toxic inhalant or x rays, provided a critically ordered sequence of exposure is observed.
Report Numbers
E 1.99:conf-790249--1
conf-790249--1
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
01/01/1979.
"conf-790249--1"
International conference on occupational lung disease, San Francisco, CA, USA, 27 Feb 1979.
Witschi, H.; Haschek, W. M.; Meyer, K. R.; Ullrich, R. L.; Dalbey, W. E.
Funding Information
W-7405-ENG-26
View MARC record | catkey: 14794509