Actions for Biomedical Imaging with Partially Coherent, Laser-Driven Plasma X-Ray Sources [electronic resource].

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Biomedical Imaging with Partially Coherent, Laser-Driven Plasma X-Ray Sources [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy. Office of Science, 2008.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Additional Creators
Argonne National Laboratory, United States. Department of Energy. Office of Science, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Ultrafast, high-intensity laser pulses incident upon condensed matter targets are used to generate high-density plasmas that emit x-ray pulses with sub-picosecond temporal length and significant transverse coherence. The short pulse length has been exploited for ultrafast dynamics measurements of solvated transition metal complexes by XAFS spectroscopy. The high transverse coherence of the x-rays has been used for in-line holographic hard x-ray imaging of biomedical materials and tissues. This imaging method is more than a thousand times more sensitive to density variations of tissues than conventional absorption methods and enables imaging of soft tissues with high contrast without the use of contrast agents. The presentation will discuss the principles of the technique and its application to the imaging of murine livers with various tumors. The specific focus of this work rests on the imaging of the angiogenesis during the development of hepatocellular carcinoma and other cancers metastasizing in the liver.
Report Numbers
E 1.99:1122581
Subject(s)
Note
Published through SciTech Connect.
06/04/2008.
APS Colloquium Series, Advanced Photon Source (APS) at Argonne National Laboratory, Argonne, Illinois (United States), presented on June 04, 2008.
Rose-Petruck, Christoph.
Funding Information
ACO2-06CH11357
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