A restraint-free small animal SPECT imaging system with motion tracking [electronic resource].
- Washington, D.C. : United States. Dept. of Energy. Office of Energy Research, 2005.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
- Physical Description:
- 638- 644 : digital, PDF file
- Additional Creators:
- Thomas Jefferson National Accelerator Facility (U.S.), United States. Department of Energy. Office of Energy Research, and United States. Department of Energy. Office of Scientific and Technical Information
- Restrictions on Access:
- Free-to-read Unrestricted online access
- We report on an approach toward the development of a high-resolution single photon emission computed tomography (SPECT) system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/unanesthetized mice. An infrared (IR)-based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with submillimeter accuracy. The high-resolution, gamma imaging detectors are based on pixellated NaI(Tl) crystal scintillator arrays, position-sensitive photomultiplier tubes, and novel readout circuitry requiring fewer analog-digital converter (ADC) channels while retaining high spatial resolution. Two SPECT gamma camera detector heads based upon position-sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the tracking system will be used for motion correction during the tomographic image reconstruction.
- Report Numbers:
- E 1.99:jlab-phy-05-463
E 1.99: doe/er/40150-4089
- Other Subject(s):
- Published through SciTech Connect.
IEEE Transactions on Nuclear Science 52 3 ISSN 0018-9499; IETNAE FT
Gleason, S.S.; Smith, M.F.; Welch, B.L.; Popov, V.; Goddard, J.; Kross, B.; Majewski, S.; Weisenberger, A.G.; Paulus, M.J.; Wojcik, R.; Meikle, S.R.; Pomper, M.
- Funding Information:
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