{sup 188}Rhenium-HEDP in the Treatment of Pain in Bone Metastases [electronic resource].

Published:: Washington, D.C. : United States. Dept. of Energy. Office of Energy Research, 1999.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description:: 6 pages : digital, PDF file
Additional Creators:: Oak Ridge National Laboratory, United States. Department of Energy. Office of Energy Research, and United States. Department of Energy. Office of Scientific and Technical Information

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Summary:

Systemic use of radiopharmaceuticals is a recognized alternative method for the treatment of pain in patients with multiple bone metastasis. A new option, ¹⁸⁸Re-HEDP is proposed, using generator-obtained ¹⁸⁸Rhenium (β energy = 2.1 MeV, γ energy = 155 keV, half-life = 16.9 hours). After establishing parameters of biodistribution, dosimetry and image acquisition in mice, rats and rabbits, Phase I and II studies were conducted on 12 patients with multiple metastasis from carcinomas, with pain surpassing other analgesic options. More than 50% pain relief was found in 91% of the patients, with total relief during a variable period in 41% of them allowing opiate and other analgesic drugs to be decreased or withdrawn, and showing a lower bone marrow contribution to total absorbed dose than that reported for other similar radiopharmaceuticals. Further study of this option is recommended in order to determine higher dose protocols without toxic bone marrow reaction possibilities.

Report Numbers:

E 1.99:ornl/cp-102530
E 1.99: kp 14 01 02 0
kp 14 01 02 0
ornl/cp-102530

Subject(s):

Radiology And Nuclear Medicine

Other Subject(s):

Note:

Published through SciTech Connect.
01/18/1999.
"ornl/cp-102530"
" kp 14 01 02 0"
"KP 14 01 02 0"
International Seminar on Therapeutic Applications of Radiopharmaceuticals, Hyderabad (IN), 01/18/1999--01/22/1999.
Martinez, G.; Knapp, F.F., Jr.; Gaudiano, J.; Savio, E.; Robles, A.; Muniz, S.; Leon, A.; Verdera, S.; Hermida, J.C.

Funding Information:

AC05-96OR22464

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