Actions for Major compound-dependent variations of {sup 10}B(n{alpha}){sup 7} Li RBE for the 9L RAT gliosarcoma in vitro and in vivo [electronic resource].

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Major compound-dependent variations of {sup 10}B(n{alpha}){sup 7} Li RBE for the 9L RAT gliosarcoma in vitro and in vivo [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 1991.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description
19 pages : digital, PDF file
Additional Creators
Brookhaven National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Relative biological effectiveness (RBE) values for the high linear-energy-transfer (LET) radiations produced during born neutron capture therapy (BNCT) were determined using the 9L rat gliosarcorna both in vitro and as an intracerebral tumor. In the absence of ¹°B, the combined effect of the recoiling protons from the ¹⁴N(n,p)¹⁴C and the ¹H(n,n′)p reactions, compared to an iso-effect endpoint produced by 250 kVp x-rays, yielded RBEs for these high-LET protons of 4.4 in vitro and 3.8 in an in vivo/in vitro assay. RBEs for the ¹°B(n,α)⁷Li reaction were calculated from cell survival data following reactor irradiation in the presence or in the absence of the either of the amino acid, p-boronophenylalanine (BPA) or the sulfhydryl dodecaborane dimer (BSSB). With BPA, RBE values ranged from 3.5 to 11.4, while under the same set of conditions with BSSB, RBE values ranged from 1.1 to 4.3. In vitro, higher RBEs for the ¹°B(n,α)⁷Li reaction using BPA than with BSSB suggest a difference in distribution of ¹°B relative to the nucleus.
Report Numbers
E 1.99:bnl--47080
E 1.99: conf-9109343--1
conf-9109343--1
bnl--47080
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Note
Published through SciTech Connect.
12/31/1991.
"bnl--47080"
" conf-9109343--1"
"DE92007608"
International workshop and plenary meeting,Petten (Netherlands),14-21 Sep 1991.
Makar, M.S.; Slatkin, D.N.; Joel, D.D.; Coderre, J.A.; Micca, P.L.; Nawrocky, M.M.
Funding Information
AC02-76CH00016
View MARC record | catkey: 14794739