Light ion irradiation for unfavorable soft tissue sarcoma [electronic resource].

Published:: Washington, D.C. : United States. Dept. of Energy, 1990.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy.
Physical Description:: Pages: (23 pages) : digital, PDF file
Additional Creators:: Lawrence Berkeley National Laboratory
United States. Department of Energy
United States. Department of Health and Human Services
United States. Department of Energy. Office of Scientific and Technical Information
Access Online:: www.osti.gov

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Summary:

Between 1978 and 1989, 32 patients with unfavorable soft tissue sarcoma underwent light ion (helium, neon) irradiation with curative intent at Lawrence Berkeley Laboratory. The tumors were located in the trunk in 22 patients and head and neck in 10. Macroscopic tumor was present in 22 at the time of irradiation. Two patients had tumors apparently induced by previous therapeutic irradiation. Follow-up times for surviving patients ranged from 4 to 121 months (median 27 months). The overall 3-year actuarial local control rate was 62%; the corresponding survival rate was 50%. The 3-year actuarial control rate for patients irradiated with macroscopic tumors was 48%, while none of the patients with microscopic disease developed local recurrence (100%). The corresponding 3-year actuarial survival rates were 40% (macroscopic) and 78% (microscopic). Patients with retroperitoneal sarcoma did notably well; the local control rate and survival rate were 64% and 62%, respectively. Complications were acceptable; there were no radiation related deaths, while two patients (6%) required operations to correct significant radiation-related injuries. These results appear promising compared to those achieved by low -LET irradiation, and suggest that this technique merits further investigation.

Subject(s):

Radiology And Nuclear Medicine

Note:

Published through SciTech Connect.
09/01/1990.
"lbl-31546"
" conf-9009207--1"
"DE92017024"
": CA19138"
9. annual meeting of the European Society of Therapeutic Radiology and Oncology (ESTRO), Montecatini Terme (Italy), 12-15 Sep 1990.
Phillips, T.L.; Castro, J.R.; Linstadt, D.; Petti, P.L.; Collier, J.M.; Daftari, I.; Schoethaler, R.; Rayner, A.

Funding Information:

AC03-76SF00098

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