Actions for Establishment Of Subculture Protocol For The Maintenance Of Bxpc3 Cell Health In Preparation For In Vitro Cytoxicology Screening Of Calcium Phosphosilicate Nanoparticles

Email RIS file
Bookmark
Report an Issue

Establishment Of Subculture Protocol For The Maintenance Of Bxpc3 Cell Health In Preparation For In Vitro Cytoxicology Screening Of Calcium Phosphosilicate Nanoparticles

Author
Kumpf, Danielle
Published
[University Park, Pennsylvania] : Pennsylvania State University, 2015.
Physical Description
1 electronic document
Additional Creators
Adair, James H. and Schreyer Honors College
Access Online

Availability

I Want It
I Want It

Finding items...

Restrictions on Access
Open Access.
Summary
Current treatment methods utilized for the treatment of pancreatic cancer have historically been largely unsuccessful, leading to a 5-year survival rate of <4%. A major obstacle contributing to past failures in treating pancreatic cancer is an inability to deliver high dosages of chemotherapeutic drugs to the tumor site. This project seeks to investigate calcium phosphosilicate nanoparticles targeted to the pancreas for specialized drug delivery. A novel cell culture protocol is described to afford healthy pancreatic tumor cells from the primary cell line BxPC3 for in vitro testing. Current studies are investigating the use of variations of the gastrin peptide as a pancreas-targeting agent for tumor specific delivery of chemotherapeutic drugs. Future studies hope calcium phosphosilicate nanoparticles will allow for specialized delivery of chemotherapeutics to tumor sites, thereby treating cancer with greater efficiency and minimizing harmful drug side effects throughout healthy tissue.
Other Subject(s)
Genre(s)
Dissertation Note
B.S. Pennsylvania State University 2015.
Technical Details
The full text of the dissertation is available as an Adobe Acrobat .pdf file ; Adobe Acrobat Reader required to view the file.
View MARC record | catkey: 15440127