Instruments of the Earth Radiation Budget Experiment (ERBE) have operated on three different Earth-orbiting spacecraft. The Earth Radiation Budget Satellite (ERBS) is operated by the National Aeronautics and Space Administration (NASA), and the NOAA 9 and NOAA 10 weather satellites are operated by the National Oceanic and Atmospheric Administration (NOAA). This paper is one of a series that describes the ERBE mission, in-orbit environments, instrument design and operational features, and data processing and validation procedures. This paper also describes the in-flight operations for the ERBE nonscanner instruments aboard the ERBS, NOAA 9, and NOAA 10 spacecraft from January 1990 through December 1990. Validation and archives of radiation measurements made by ERBE nonscanner instruments during this period were completed in August 1996. This paper covers normal and special operations of the spacecraft and instruments, operational anomalies, and the responses of the instruments to in-orbit and seasonal variations in the solar environment.