Effects of Caudal Elevation on Testicular Function in Rats : Separation of Effects on Spermatogenesis and Steroidogenesis
- Veeramachaneni, D. N. R.
- Physical Description:
- 1 electronic document
- Additional Creators:
- Ball, R., Amann, R. P., Deaver, D. R., Musacchia, X. J., and Hammerstedt, R. H.
- Restrictions on Access:
- Unclassified, Unlimited, Publicly available.
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- A variety of biologic processes are perturbed when exposed to microgravity (space flight) for more than 7 days, including testicular function. Suspension of rats in a special harness (caudal elevation) to induce thoracic pooling of blood fluids and remove the support function of the hind limbs is used to mimic, on earth, the effects of microgravity encountered during space flight. Typically, this induces cryptorchidism in male rats. Three experiments were conducted to differentiate the effects of caudal elevation (30 deg angle) and anatomic location of testes on spermatogenesis and steroidogenesis. Rats were subjected to caudal elevation for 7 days using either a tail harness or a whole-body harness. Testes of rats fell into the abdominal cavity when a tail harness was used, but ligation of the iguinal canal prevented this repositioning. For rats with abdominal testes, testicular weight was reduced (P less than 0.05) and histology of testes was abnormal; the number of spermatids per gram parenchyma was lower (P less than 0.05) in tail-suspended rats compared with control rats.
- Other Subject(s):
- NASA Technical Reports Server (NTRS) Collection.
- Document ID: 19980211148.
Journal of Andrology; Volume 13; No. 3; 224-231.
- Copyright, Distribution as joint owner in the copyright.
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