Grand unified theories (GUT) such as SU(5), with spontaneous symmetry breaking, can lead more naturally to a globally baryon symmetric big bang cosmology with a domain structure than to a totally asymmetric cosmology. The symmetry is broken at random in causally independent domains, favoring neither a baryon nor an antibaryon excess on a universal scale. Because of the additional freedom in the high-energy physics allowed by such GUT gauge theories, new observational tests may be possible. Arguments in favor of this cosmology and various observational tests are discussed.