Actions for Lymphoid cell kinetics under continuous low dose-rate gamma irradiation : A comparison study

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Lymphoid cell kinetics under continuous low dose-rate gamma irradiation : A comparison study

Author
Foster, B. R.
Published
Feb 12, 1975.
Physical Description
1 electronic document
Online Version

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Summary
The mechanism of cell proliferation is studied in the lymphoid tissue of the mouse spleen under the stress of continuous irradiation at a dose-rate of 10 roentgens per day for 105 days. Autoradiography and specific labeling with tritiated thymidine were utilized. It was found that at least four compensatory mechanisms maintained a near-steady state of cellular growth: (1) an increase in the proportion of PAS-positive cells which stimulate mitotic activity, (2) maturation arrest of proliferating and differentiating cells which tend to replenish the cells damaged or destroyed by irradiation, (3) an increase in the proportion of cells proliferating, and (4) an increase in the proportion of precursor cells. The results are compared to previous findings observed in the thymus.
Other Subject(s)
Collection
NASA Technical Reports Server (NTRS) Collection.
Note
Document ID: 19750008141.
Accession ID: 75N16213.
NASA-CR-142068.
Terms of Use and Reproduction
No Copyright.
View MARC record | catkey: 15741255