Molecular biology of arrestins [electronic resource] / edited by Louis M. Luttrell
- Published:
- [Place of publication not identified] : Elsevier Science & Technology, 2013.
- Physical Description:
- 1 online resource
- Additional Creators:
- Luttrell, Louis M.
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- Series:
- Contents:
- Machine generated contents note: 1.Arrestins Come of Age: A Personal Historical Perspective -- 1.Introduction / Robert J. Lefkowitz -- 2."Prehistory" Of Arrestins / Robert J. Lefkowitz -- 3.A Family of 7 Transmembrane Receptors' / Robert J. Lefkowitz -- 4.The GRK and Arrestin Families / Robert J. Lefkowitz -- 5.Arrestins and Desensitization / Robert J. Lefkowitz -- 6.Arrestins and Endocytosis / Robert J. Lefkowitz -- 7.Arrestins and Signaling / Robert J. Lefkowitz -- 8.Biased Signaling / Robert J. Lefkowitz -- 9.Bar Code Hypothesis / Robert J. Lefkowitz -- 10.Other Receptors, Other Functions / Robert J. Lefkowitz -- 11.Future Perspectives / Robert J. Lefkowitz -- References / Robert J. Lefkowitz -- 2.True Arrestins and Arrestin-Fold Proteins: A Structure-Based Appraisal / Robert J. Lefkowitz -- 1.Introduction / Laurence Aubry / Gérard Klein -- 2.True Arrestins: A Structure Adapted to Multiple Scaffolding / Laurence Aubry / Gérard Klein -- 3.Novel Arrestin-Related Proteins / Laurence Aubry / Gérard Klein -- 4.Other Arrestin-Fold Proteins / Laurence Aubry / Gérard Klein -- 5.Are Arrestins and Arrestin-Fold Proteins Related by a Shared Mechanism for Their Function? / Laurence Aubry / Gérard Klein -- 6.Conclusion and Perspectives / Laurence Aubry / Gérard Klein -- References / Laurence Aubry / Gérard Klein -- 3.Structural Determinants of Arrestin Functions / Laurence Aubry / Gérard Klein -- 1.Introduction / Vsevolod V. Gurevich / Eugenia V. Gurevich -- 2.What the Crystal Structure Reveals, and What it Does Not / Vsevolod V. Gurevich / Eugenia V. Gurevich -- 3.How do Arrestins Fit Receptors? / Vsevolod V. Gurevich / Eugenia V. Gurevich -- 4.Interactions with Other Signaling Proteins / Vsevolod V. Gurevich / Eugenia V. Gurevich -- 5.Designing Signaling-Biased Arrestin Mutants / Vsevolod V. Gurevich / Eugenia V. Gurevich -- 6.Conclusions: Where do we go from Here? / Vsevolod V. Gurevich / Eugenia V. Gurevich -- Acknowledgments / Vsevolod V. Gurevich / Eugenia V. Gurevich -- References / Vsevolod V. Gurevich / Eugenia V. Gurevich -- 4.Arrestins: Role in the Desensitization, Sequestration, and Vesicular Trafficking of G Protein-Coupled Receptors / Vsevolod V. Gurevich / Eugenia V. Gurevich -- 1.Introduction / Cornelia Walther / Stephen S.G. Ferguson -- 2.Arrestins in GPCR Desensitization / Cornelia Walther / Stephen S.G. Ferguson -- 3.Arrestins in GPCR Trafficking / Cornelia Walther / Stephen S.G. Ferguson -- 4.Conclusions / Cornelia Walther / Stephen S.G. Ferguson -- Acknowledgments / Cornelia Walther / Stephen S.G. Ferguson -- References / Cornelia Walther / Stephen S.G. Ferguson -- 5.Arrestins as Regulators of Kinases and Phosphatases / Cornelia Walther / Stephen S.G. Ferguson -- 1.Introduction / Louis M. Luttrell / William E. Miller -- 2.Arrestins as GPCR Effectors / Louis M. Luttrell / William E. Miller -- 3.Positive and Negative Regulation of Kinase Pathways / Louis M. Luttrell / William E. Miller -- 4.Arrestin-Regulated Kinase and Phosphatase Pathways / Louis M. Luttrell / William E. Miller -- 5.Conclusions / Louis M. Luttrell / William E. Miller -- Acknowledgments / Louis M. Luttrell / William E. Miller -- References / Louis M. Luttrell / William E. Miller -- 6.11-Arrestins: Modulators of Small GTPase Activation and Function / Louis M. Luttrell / William E. Miller -- 1.Introduction / Audrey Claing -- 2.Ras Family GTPases / Audrey Claing -- 3.Rho Family GTPases / Audrey Claing -- 4.Rab Family GTPases / Audrey Claing -- 5.ARF Family GTPases / Audrey Claing -- 6.Ran Family GTPases / Audrey Claing -- 7.Perspectives and Future Directions / Audrey Claing -- 8.Conclusions / Audrey Claing -- References / Audrey Claing -- 7.Arrestins and Protein Ubiquitination / Audrey Claing -- 1.Introduction / Reddy Peera Kommaddi / Sudha K. Shenoy -- 2.Ubiquitination of Arrestins / Reddy Peera Kommaddi / Sudha K. Shenoy -- 3.Deubiquitination of Arrestins / Reddy Peera Kommaddi / Sudha K. Shenoy -- 4.Arrestins Act as Adaptors for Ubiquitination / Reddy Peera Kommaddi / Sudha K. Shenoy -- 5.Arrestins and Seven-Transmembrane Receptor Deubiquitination / Reddy Peera Kommaddi / Sudha K. Shenoy -- 6.Arrestin-Like Proteins / Reddy Peera Kommaddi / Sudha K. Shenoy -- 7.Conclusions / Reddy Peera Kommaddi / Sudha K. Shenoy -- Acknowledgment / Reddy Peera Kommaddi / Sudha K. Shenoy -- References / Reddy Peera Kommaddi / Sudha K. Shenoy -- 8.Arrestins in Actin Reorganization and Cell Migration / Reddy Peera Kommaddi / Sudha K. Shenoy -- 1.Introduction / Kathryn A. DeFea -- 2.β-Arrestins as Regulators of Gradient Sensing for Chemokine Receptors / Kathryn A. DeFea -- 3.β-Arrestins as Regulators of Actin Assembly / Kathryn A. DeFea -- 4.Regulation of Kinase Activities by β-Arrestins / Kathryn A. DeFea -- 5.Additional Roles for β-Arrestins and Chemotaxis In Vivo / Kathryn A. DeFea -- 6.Role of β-Arrestin-Dependent Chemotaxis in Health and Disease / Kathryn A. DeFea -- 7.Concluding Remarks / Kathryn A. DeFea -- References / Kathryn A. DeFea -- 9.The Role of Arrestins in Development / Kathryn A. DeFea -- 1.Introduction / Melanie Philipp / Tama Evron / Marc G. Caron -- 2.β-Arrestins in Model Organisms / Melanie Philipp / Tama Evron / Marc G. Caron -- 3.The Function of Arrestins in Invertebrates / Melanie Philipp / Tama Evron / Marc G. Caron -- 4.β-Arrestins in Vertebrate Development / Melanie Philipp / Tama Evron / Marc G. Caron -- 5.Conclusions / Melanie Philipp / Tama Evron / Marc G. Caron -- Acknowledgments / Melanie Philipp / Tama Evron / Marc G. Caron -- References / Melanie Philipp / Tama Evron / Marc G. Caron -- 10.The Role of Arrestins in Visual and Disease Processes of the Eye / Melanie Philipp / Tama Evron / Marc G. Caron -- 1.Visual Arrestin Nomenclature / W. Clay Smith -- 2.The Function of Visual Arrestins in Quenching; Phototransduction / W. Clay Smith -- 3.Splice Variants of Arrestin1 / W. Clay Smith -- 4.Arrestins in Cone Photoreceptors / W. Clay Smith -- 5.Translocation of Visual Arrestins / W. Clay Smith -- 6.New Roles for Arrestin1 in the Retina / W. Clay Smith -- 7.Arrestins in Disease Processes in the Eye / W. Clay Smith -- 8.The Future for Visual Arrestins / W. Clay Smith -- References / W. Clay Smith -- 11.β-Arrestins in the Central Nervous System / W. Clay Smith -- 1.Introduction: Arrestins'and GRK in the Central Nervous System / Camille Latapy / Jean Martin Beaulieu -- 2.Arrestins and GRK in Dopaminergic Neurotransmission / Camille Latapy / Jean Martin Beaulieu -- 3.Arrestins in Serotonergic Neurotransmission / Camille Latapy / Jean Martin Beaulieu -- 4.Arrestins in Noradrenergic Neurotransmission / Camille Latapy / Jean Martin Beaulieu -- 5.Arrestins in Opioid Receptor Signaling / Camille Latapy / Jean Martin Beaulieu -- 6.Arrestins and Corticotropin Receptors / Camille Latapy / Jean Martin Beaulieu -- 7.Other β-arrestin-Dependent Behavior / Camille Latapy / Jean Martin Beaulieu -- 8.Conclusions / Camille Latapy / Jean Martin Beaulieu -- Acknowledgment / Camille Latapy / Jean Martin Beaulieu -- References / Camille Latapy / Jean Martin Beaulieu -- 12.Arrestins in the Cardiovascular System / Camille Latapy / Jean Martin Beaulieu -- 1.Introduction / Anastasios Lymperopoulos / Ashley Bathgate -- 2.Cardiovascular Adrenergic Receptors and ßarrs / Anastasios Lymperopoulos / Ashley Bathgate -- 3.Cardiovascular Angiotensin II Receptors and ßarrs / Anastasios Lymperopoulos / Ashley Bathgate -- 4.Other Cardiovascular GPCRs and ßarrs / Anastasios Lymperopoulos / Ashley Bathgate -- 5.Cardiovascular Non-GPCRs and ßarrs / Anastasios Lymperopoulos / Ashley Bathgate -- 6.Biased Agonism/Antagonism of Cardiovascular GPCR Cigands / Anastasios Lymperopoulos / Ashley Bathgate -- 7.Perspectives and Future Directions / Anastasios Lymperopoulos / Ashley Bathgate -- 8.Conclusions / Anastasios Lymperopoulos / Ashley Bathgate -- References / Anastasios Lymperopoulos / Ashley Bathgate -- 13.Arrestins in Bone / Anastasios Lymperopoulos / Ashley Bathgate -- 1.Introduction / Brittany N. Bohinc / Diane Gesty-Palmer -- 2.Arrestin Signaling: A New Dimension to GCPR Signaling in Bone / Brittany N. Bohinc / Diane Gesty-Palmer -- 3.Functional Selectivity in Bone / Brittany N. Bohinc / Diane Gesty-Palmer -- 4.Arrestin Signaling Effects in Bone / Brittany N. Bohinc / Diane Gesty-Palmer -- 5.Perspectives and Future Directions / Brittany N. Bohinc / Diane Gesty-Palmer -- 6.Conclusions / Brittany N. Bohinc / Diane Gesty-Palmer -- Acknowledgments / Brittany N. Bohinc / Diane Gesty-Palmer -- References / Brittany N. Bohinc / Diane Gesty-Palmer -- 14.&dbeta;-Arrestins in the Immune-System / Brittany N. Bohinc / Diane Gesty-Palmer -- 1.Introduction / Paul W. Noble / Dianhua Jiang / Ting Xie / Jiurong Liang -- 2.β-Arrestins in Innate Immunity / Dianhua Jiang / Ting Xie / Jiurong Liang / Paul W. Noble -- 3.β-Arrestins in Adaptive Immunity / Dianhua Jiang / Ting Xie / Jiurong Liang / Paul W. Noble -- 4.β-Arrestins and Structural Cells / Dianhua Jiang / Ting Xie / Jiurong Liang / Paul W. Noble -- 5.β-Arrestins Regulate Immune Signaling Pathways / Dianhua Jiang / Ting Xie / Jiurong Liang / Paul W. Noble -- 6.Role of β-Arrestins in Human Diseases / Dianhua Jiang / Ting Xie / Jiurong Liang / Paul W. Noble -- 7.β-Arrestins in Therapeutic Development for Inflammatory Diseases / Dianhua Jiang / Ting Xie / Jiurong Liang / Paul W. Noble -- References / Dianhua Jiang / Ting Xie / Jiurong Liang / Paul W. Noble -- 15.The Role of B-Arrestins in Cancer / Dianhua Jiang / Ting Xie / Jiurong Liang / Paul W. Noble -- 1.Introduction / Philip Michael Sobolesky / Omar Moussa -- 2.ARRBs and Cancer-Associated Cell Phenotypes / Philip Michael Sobolesky / Omar Moussa -- 3.The Role of ARRBs in Cancer / Philip Michael Sobolesky / Omar Moussa -- 4.Conclusions / Philip Michael Sobolesky / Omar Moussa -- Acknowledgments / Philip Michael Sobolesky / Omar Moussa -- and Contents note continued: References / Philip Michael Sobolesky / Omar Moussa -- 16.Arrestins in Metabolic Regulation / Philip Michael Sobolesky / Omar Moussa -- 1.A Short Introduction to Metabolic Regulation / Jian Zhao / Gang Pei -- 2.Functional Roles of β-Arrestins in Regulation of Whole-Body Energy Balance and Body Weight Control / Jian Zhao / Gang Pei -- 3.Functional Role of β-Arrestins in Regulation of Carbohydrate and Lipid Homeostasis / Jian Zhao / Gang Pei -- 4.Conclusions / Jian Zhao / Gang Pei -- References / Jian Zhao / Gang Pei -- 17.Systems Analysis of Arrestin Pathway Functions / Jian Zhao / Gang Pei -- 1.G Protein-Coupled Receptor Signaling Activity / Stuart Maudsley / Sana Siddiqui / Bronwen Martin -- 2.Signaling Diversity Among GPCRs / Bronwen Martin / Stuart Maudsley / Sana Siddiqui -- 3.Systems Analysis of Receptor Signaling Systems / Stuart Maudsley / Sana Siddiqui / Bronwen Martin -- 4.Functional Analyses of Arrestin Signaling Paradigms / Stuart Maudsley / Sana Siddiqui / Bronwen Martin -- 5.Conclusions / Stuart Maudsley / Sana Siddiqui / Bronwen Martin -- Acknowledgments / Stuart Maudsley / Sana Siddiqui / Bronwen Martin -- References / Stuart Maudsley / Sana Siddiqui / Bronwen Martin -- 18.Arrestin Pathways as Drug Targets / Stuart Maudsley / Sana Siddiqui / Bronwen Martin -- 1.Introduction / Louis M. Luttrell -- 2.Biased GPCR Agonism / Louis M. Luttrell -- 3.The Many Faces of Arrestin-Dependent Biased Agonism / Louis M. Luttrell -- 4.The Conserved Arrestin-Dependent Signaling Repertoire / Louis M. Luttrell -- 5.Conclusions / Louis M. Luttrell -- Acknowledgments / Louis M. Luttrell -- References / Louis M. Luttrell.
- Summary:
- This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field.
- Subject(s):
- ISBN:
- 9780123947895 (electronic bk.)
0123947898 (electronic bk.)
1299666485 (electronic bk.)
9781299666481 (electronic bk.)
9780123944405
0123944406
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