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Aging : the longevity dividend / edited by S. Jay Olshansky, University of Illinois at Chicago, George M. Martin, University of Washington, James L. Kirkland, Mayo Clinic

Published
Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press, [2016]
Physical Description
x, 243 pages ; 27 cm.
Additional Creators
Olshansky, Stuart Jay, 1954-, Martin, George M., 1927-, and Kirkland, James (James L.)

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Series
Contents
Introduction. The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Healthspan and Lifespan / Felipe Sierra -- Part I: Basic Mechanisms of Biological Aging -- The Role of the Microenvironmental Niche in Declining Stem Cell Functions Associated with Biological Aging / Nathan A. DeCarolis, Elizabeth D. Kirby, Tony Wyss-Coray, and Theo D. Palmer -- Biochemical Genetic Pathways that Modulate Aging in Multiple Species / Alessandro Bitto, Adrienne M. Wang, Christopher F. Bennett, and Matt Kaeberlein -- DNA Damage, DNA Repair, Aging, and Neurodegeneration / Scott Maynard, Evandro Fei Fang, Morten Scheibye-Knudsen, Deborah L. Croteau, and Vilhelm A. Bohr -- How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative / Fuki M. Hisama, Junko Oshima, and George M. Martin -- Dissecting the Mechanisms Underlying Successful Human Healthspan and Lifespan / Sofiya Milman and Nir Barzilai -- The Companion Dog as a Model for the Longevity Dividend / Kate E. Creevy, Steven N. Austad, Jessica M. Hoffman, Dan G. O'Neill, and Daniel E.L. Promislow -- Part II: Clinical and Translational Aspects of Aging -- Translating the Science of Aging into Therapeutic Intervention / James L. Kirkland -- Interventions for Human Frailty: Physical Activity as a Model / Linda P. Fried -- The Aging Heart / Ying Ann Chiao and Peter S. Rabinovitch -- Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond / Dudley W. Lamming -- Metformin: A Hopeful Promise in the Aging Research / Marta G. Novelle, Ahmed Ali, Carlos Dieguez, Michel Bernier, and Rafael de Cabo -- Part III: Societal Implications of Delayed Aging -- Articulating the Case for the Longevity Dividend / S. Jay Olshansky -- The Economic Promise of Delayed Aging / Dana Goldman -- Past, Present, and Future of Healthy Life Expectancy / Hiram Beltrán-Sánchez, Samir Soneji, and Eileen M. Crimmins -- Has the Rate of Human Aging Already Been Modified? / S. Jay Olshansky.
Summary
"Aging affects us all and is characterized not only by increasing frailty but by increased susceptibility to conditions such as Alzheimer's, cardiovascular disease, and cancer. We are gaining an increasing understanding of the molecular mechanisms underlying aging, however, and uncovering clues to how life may be prolonged. This book examines the biological basis of aging and research into strategies that may extend lifespan"--
Subject(s)
ISBN
9781621820802 hardcover
1621820807 hardcover
9781621821632
1621821633
Bibliography Note
Includes bibliographical references and index.
View MARC record | catkey: 17036526