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The p53 protein : from cell regulation to cancer / edited by Guillermina Lozano, The University of Texas M.D. Anderson Cancer Center, Arnold J. Levine, Institute for Advanced Study

Published
Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press, [2016]
Physical Description
xi, 504 pages : illustrations (chiefly color) ; 27 cm.
Additional Creators
Lozano, Guillermina and Levine, Arnold J. (Arnold Jay), 1939-

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Contents
Machine generated contents note: I.THE STRUCTURE AND FUNCTIONS OF THE p53 PROTEIN -- The Paradox of p53: What, How, and Why? / Moshe Oren -- Structural Evolution and Dynamics of the p53 Proteins / Gerry Melino -- p53 Isoforms: Key Regulators of the Cell Fate Decision / Jean-Christophe Bourdon -- The Transactivation Domains of the p53 Protein / Laura D. Attardi -- Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53 / Carol Prives -- Tumor-Suppressor Functions of the TP53 Pathway / Gemma L. Kelly -- II.THE REGULATION OF CELLULAR FUNCTIONS BY THE p53 PROTEIN -- p53 in the DNA-Damage-Repair Process / Bjorn Schumacher -- Genome Stability Requires p53 / Christine M. Eischen -- The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression / Jiandong Chen -- Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres / Steven E. Artandi -- The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence / James G. Jackson -- Autophagy and p53 / Eileen White -- The Evolution of the Ribosomal Protein--MDM2--p53 Pathway / Yangping Zhang -- Regulation of Cellular Metabolism and Hypoxia by p53 / Karen H. Vousden -- The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation / Pierre Hainaut -- p53 and the Carcinogenicity of Chronic Inflammation / Elena A. Komarova -- III.p53 MUTATIONS IN HUMAN CANCERS -- Somatic TP53 Mutations in the Era of Genome Sequencing / Gerd P. Pfeifer -- The Inherited p53 Mutation in the Brazilian Population / Gerard P. Zambetti -- Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation / Varda Rotter -- Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End / Guillermina Lozano -- Inherited TP53 Mutations and the Li-Fraumeni Syndrome / David Malkin -- IV.THE p53 PATHWAY IN HUMAN CANCERS--CLINICAL MANIFESTATIONS -- The Role of MDM2 Amplification and Overexpression in Tumorigenesis / Sean Caenepeel -- MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond / Aart G. Jochemsen -- Targeting the MDM2--p53 Protein--Protein Interaction for New Cancer Therapy: Progress and Challenges / Chao-Yie Yang -- TP53 Mutations in Breast and Ovarian Cancer / Anne-Lise Børresen-Dale -- p53 as an Effector or Inhibitor of Therapy Response / Hugues de The -- p53 and Medulloblastoma / Michael D. Taylor -- TP53 Mutations in Hypodiploid Acute Lymphoblastic Leukemia / Charles G. Mullighan -- Clinical Outcomes of TP53 Mutations in Cancers / Curtis C. Harris -- Genetic Modifiers of the p53 Pathway / Maureen E. Murphy -- Exploiting the p53 Pathway for Therapy / David Philip Lane.
Subject(s)
ISBN
9781621821335 (hardcover : alk. paper)
1621821331 (hardcover : alk. paper)
Bibliography Note
Includes bibliographical references and index.
View MARC record | catkey: 17750397