Actions for Nanobiomaterials in drug delivery : applications of nanobiomaterials

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Nanobiomaterials in drug delivery : applications of nanobiomaterials / edited by Alexandru Mihai Grumezescu

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Kidlington, Oxford, UK : William Andrew is an imprint of Elsevier, 2016.
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Grumezescu, Alexandru Mihai
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Contents
Machine generated contents note: Abbreviations / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.1.Introduction / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.1.1.Parameters of Delivery of Nanoparticles into Biological Systems / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.1.2.Intratumor Drug Release / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.1.3.Biological Clearance / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.1.4.Toxicity of Nanoparticles / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.2.Preparation and Characterization of Nanomaterials / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.2.1.Preparation / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.2.2.Characterization / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.3.Nanotechnology-Assisted Formulating of Poorly Water-Soluble Compounds / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.4.Biodegradable Polymers Used in Controlled Drug Delivery / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.5.Multifunctional Nanomaterials for Cancer Therapy / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.5.1.Targeting / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.5.2.Imaging / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.5.3.Chemotherapy / Mathangi Srinivasan / Mehdi Rajabi / Shaker A. Mousa -- 1.6.Chemical Conjugation of Nanomaterials / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.6.1.pH-Sensitive Linkages Used for Bioconjugation of Nanomaterials / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.6.2.Other Chemical Linkages Used for Bioconjugation of Nanomaterials / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 1.7.Conclusions / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- Acknowledgments / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- References / Mehdi Rajabi / Shaker A. Mousa / Mathangi Srinivasan -- 2.1.Introduction / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.2.Mechanisms of Interaction Between Dendrimers and Drug Molecules / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.3.Dendrimers as Carriers of Various Types of Drugs / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.3.1.Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.3.2.Anticancer Drugs / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.3.3.Other Drugs / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.4.Routes of Administration of Drug-Dendrimers Complexes / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.4.1.Dendrimers in Intravenous Drug Delivery / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.4.2.Dendrimers in Oral Drug Delivery / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.4.3.Dendrimers in Transdermal Drug Delivery / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.4.4.Dendrimers in Ocular Drug Delivery / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.4.5.Dendrimers in Pulmonary Drug Delivery / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 2.5.Conclusions and Further Prognosis / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- Acknowledgments / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- References / Elzbieta Mikiciuk-Olasik / Magdalena Markowicz-Piasecka -- 3.1.Introduction / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.2.siRNA: Definition, Mechanism, and Applications / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.3.Hurdles for siRNA Delivery / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.4.Strategies to Overcome the Hurdles of siRNA Delivery / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.4.1.Chemical Modifications in siRNA / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.4.2.Physical Methods for siRNA Delivery / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.4.3.Viral Carriers for siRNA Delivery / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.4.4.Non-Viral Carriers for siRNA Delivery / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.5.Liposomes: The Influence of Charge and Lipid Composition for siRNA Delivery / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.5.1.Cationic Lipid-Based siRNA Delivery Systems / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.5.2.Neutral Lipid-Based siRNA Delivery Systems / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.5.3.Anionic Lipid-Based siRNA Delivery Systems / Josimar Oliveira Eloy / Marina Claro de Souza / Juliana Palma Abriata Barcellos / Raquel Petrilli / Bryant Yung / Robert J. Lee / Juliana Maldonado Marchetti -- 3.5.4.Stealth Liposomes / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.6.Targeted Delivery of siRNA-Loaded Liposomes / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.7.Combined Therapy of siRNA-Loaded Liposomes and Conventional Small-Molecule Drugs / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.8.siRNA-Loaded Liposomes Associated with Physical Methods / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.9.siRNA-Loaded Liposomes: Clinical Studies / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 3.10.Conclusions and Perspectives / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Juliana Palma Abriata Barcellos / Juliana Maldonado Marchetti / Bryant Yung / Robert J. Lee -- References / Raquel Petrilli / Josimar Oliveira Eloy / Marina Claro de Souza / Robert J. Lee / Juliana Maldonado Marchetti / Bryant Yung / Juliana Palma Abriata Barcellos -- 4.1.Introduction / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.2.Proteins/Peptides as Therapeutics / Suresh P. Vyas / Surbhi Dubey / Udita Agrawal / Rajeev Sharma / Nishi Mody -- 4.2.1.Group I-Protein Therapeutics with Enzymatic or Regulatory Activity / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.2.2.Group II-Protein Therapeutics with Special Targeting Activity / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.2.3.Group III-Proteinaceous Vaccines / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.2.4.Group IV-Protein Diagnostics / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.3.Hurdles in Protein and Peptide Drug Delivery / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.4.Nanobiomaterials and Carriers for Protein and Peptide Drug Delivery / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.5.Classification of Polymeric Biomaterials / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.6.Methods for Protein and Peptide Nanoencapsulation / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.6.1.Emulsification -Polymerization / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.6.2.Interfacial Polymerization / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.6.3.Solvent Evaporation / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.6.4.Salting Out / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.6.5.Coacervation/Phase Separation Technique / Udita Agrawal / Suresh P. Vyas / Rajeev Sharma / Nishi Mody / Surbhi Dubey -- 4.6.6.Emulsification/Solvent Diffusion / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.6.7.Taylor Cone Jet Methods / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.7.Nanobiomaterials-Based Nanocarriers for Protein/Peptide Delivery / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.7.1.Polymeric Nanoparticles / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.8.Lipid-Based Carriers for Proteins and Peptides / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma --, Contents note continued: 4.8.1.Liposomes / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.8.2.Solid Lipid Nanoparticles / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.9.Stimuli-Responsive Systems for Protein and Peptide Delivery / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.9.1.Desirable Features of Smart Polymers for Protein and Peptide Delivery / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.9.2.Temperature-Sensitive Delivery Systems / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.9.3.Phase-Sensitive Delivery Systems / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.9.4.pH-Responsive Systems / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.9.5.Light-Responsive Systems / Rajeev Sharma / Udita Agrawal / Nishi Mody / Surbhi Dubey / Suresh P. Vyas -- 4.9.6.Electric-Responsive Systems / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.9.7.Dual- and Multistimuli Responsive Systems / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 4.10.Conclusions / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- References / Surbhi Dubey / Nishi Mody / Suresh P. Vyas / Udita Agrawal / Rajeev Sharma -- 5.1.Introduction / Uttam Chand Banerjee / Amit Kumar Mittal -- 5.2.Properties of Nanomaterials / Uttam Chand Banerjee / Amit Kumar Mittal -- 5.3.Metallic NPs and their Biomedical Prospects / Uttam Chand Banerjee / Amit Kumar Mittal -- 5.4.Methods for the Generation of Biogenic Nanomaterials / Uttam Chand Banerjee / Amit Kumar Mittal -- 5.5.The Interaction Between Biomolecules and Nanomaterials / Amit Kumar Mittal / Uttam Chand Banerjee -- 5.6.Characterization of Nanomaterials / Amit Kumar Mittal / Uttam Chand Banerjee -- 5.7.Development of Bionanomaterials for Drug Delivery, Imaging, and Diagnosis / Amit Kumar Mittal / Uttam Chand Banerjee -- 5.8.Anticancer Potential of Nanomaterials / Amit Kumar Mittal / Uttam Chand Banerjee -- 5.9.Antioxidant Potential of NPs / Amit Kumar Mittal / Uttam Chand Banerjee -- 5.10.Metal NPs as Antimicrobial Agents / Amit Kumar Mittal / Uttam Chand Banerjee -- 5.11.Toxicity Issues Associated with Metal NPs / Amit Kumar Mittal / Uttam Chand Banerjee -- 5.12.Industrial Applications of Metal NPs / Amit Kumar Mittal / Uttam Chand Banerjee -- 5.13.Conclusions and Future Prospects / Amit Kumar Mittal / Uttam Chand Banerjee -- Acknowledgments / Amit Kumar Mittal / Uttam Chand Banerjee -- References / Amit Kumar Mittal / Uttam Chand Banerjee -- 6.1.Introduction / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- 6.2.Experimental Section / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- 6.2.1.Materials / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- 6.2.2.The Magnetic Compositions and Interactions Among Their Components / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- 6.2.3.Experimental Technique / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- 6.3.Drug Release From Non-Magnetic PHB -Chitosan Systems / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- 6.4.FMR Spectroscopy of Magnetic Nanocomposites / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- 6.5.SEM Micrographs / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova -- 6.6.Equilibrium Swelling of Biodegradable Magnetic Nanocomposites / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- 6.7.Drug Transport in MNC Films / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- 6.8.Conclusions / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- Acknowledgments / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- References / Alexey Leonodovich lordanskii / Anna Vladimirovna Bychkova / Klara Zenonovna Gumargalieva / Alexandr Alexandrovich Berlin -- 7.1.Nanotechnology in Drug Delivery / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.1.1.Nanotechnology in Oral Bioavailability / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.1.2.Enhancement of Bioavailability / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.1.3.Approaches for Enhancement of Absorption of Orally Administered Drugs / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.1.4.Excipient Selection / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.1.5.Factors Affecting the Choice of Excipients for Lipid-Based Formulations / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.1.6.Lipids in Bioavailability / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.1.7.Intestinal Drug Dissolution / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.1.8.Lipids and Drug Transporter Proteins / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.1.9.Lipid-Based Formulations in Bioavailability Enhancement / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.1.10.Approaches for the Development of Lipid-Based Formulations (Solid and Semi-Solid) / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.2.Solid Lipid Nanoparticles / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.2.1.Advantages of SLNs / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.2.2.Influence of Lipids and Surfactants / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.2.3.Stability of SLNs / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.3.Nanotechnology in Lymphatic Targeting / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.3.1.What Are Lymphatics and Their Role? / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.3.2.Necessity of Delivering Drugs to the Lymphatics / Sridhar Karthik / Ranganathan Hariprasad / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram -- 7.3.3.Role of Lipids in Absorption of Drugs to the Lymphatics / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.3.4.Is Targeting to the Lymphatics Possible, Factors Necessary to Achieve Lymphatic Targeting and by What Routes / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.3.5.Current Status and Future Perspectives of Lymphatic Targeting / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.4.Nanocarriers in Neuropharmaceuticals / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.4.1.BBB Drug-Targeting Strategies / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.4.2.Surface-Modified Polymeric Nanocarriers / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.4.3.Methods for Surface-Modified Nanocarriers / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.4.4.Functionalized Nanocarriers for Drug Transport Across the BBB via Transport Vectors / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.5.Carbon Nanotubes / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.5.1.Types of CNTs / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.5.2.Production of Carbon Nanotubes / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad / Habibur Rahman / Balakumar Krishnamoorthy --, Contents note continued: 7.5.3.Mechanism of Cellular Uptake / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.5.4.Applications of CNTs in Drug Delivery / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.5.5.Toxicity of CNTs / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 7.6.Conclusions / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- References / Habibur Rahman / Balakumar Krishnamoorthy / Natarajan Tamilselvan / Karthik Siram / Sridhar Karthik / Ranganathan Hariprasad -- 8.1.Introduction / George Dan Mogoginu / Alexandru Mihai Grumezescu / Ludovic Everard Bejenaru / Cornelia Bejenaru -- 8.2.Liposomes / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.2.1.Natural and Semisynthetic Polymers for Liposome Formulations / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.2.2.Synthetic Polymer-Based Liposomes / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.3.Niosomes / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.4.Polymeric Nanoparticles / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.4.1.Natural Polymers for Nanoparticle Formulations / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.4.2.Semisynthetic Polymers / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.4.3.Synthetic Polymers / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.5.Therapeutic Polymers / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.5.1.Polymeric Micelles / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.5.2.Dendrimers / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.5.3.Colloidal Nanogels / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.5.4.Polymeric Artificial Cells / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 8.6.Conclusions and Future Perspectives / Alexandru Mihai Grumezescu / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru -- Acknowledgments / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- References / George Dan Mogoginu / Cornelia Bejenaru / Ludovic Everard Bejenaru / Alexandru Mihai Grumezescu -- 9.1.Introduction / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.2.Magnetic Nanoparticle Synthesis Methods / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.2.1.Chemical Synthesis of Magnetic Nanoparticles / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Doga Kavaz / Öznur Akbal / Göknur Kara / Cem Bayram -- 9.2.2.Green Chemistry / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.2.3.Magnetosomes-A Biological Source for Magnetic Nanoparticles / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.3.Magnetic Nanoparticles Modifications / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.3.1.Functionalization and Encapsulation with Natural Polymers / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.3.2.Functionalization and Encapsulation with Synthetic Polymers / Öznur Akbal / Göknur Kara / Cem Bayram / Doga Kavaz / Ekin Çelik / Ebru Erdal / Emir Baki Denkbas -- 9.3.3.Ligand Modifications and Targeting / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.3.4.Magnetic Resonance Imaging / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.3.5.Hyperthermia / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.3.6.Gene Therapy / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.3.7.Drug Delivery / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- 9.4.Conclusions / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- References / Emir Baki Denkbas / Ekin Çelik / Ebru Erdal / Cem Bayram / Öznur Akbal / Göknur Kara / Doga Kavaz -- Abbreviations / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.1.Introduction / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.2.Blood-Brain Barrier / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.3.Endothelial Cells / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.3.1.Tight Junctions / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.3.2.Adherens Junction / Palazzo Claudio / Karim Reatul / Evrard Brigitte / Piel Geraldine -- 10.3.3.ATP-Binding Cassette Transporters / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.3.4.Transport Systems / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.4.Astrocytes / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.5.Pericytes / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.6.Factors Influencing BBB Penetration / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.7.Hydrogen Bonding / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.8.Plasma Area Under the Curve / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.9.Molecular Weight / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.10.Parameters to Evaluate Brain Permeation / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.11.Influx Clearance into the Brain / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.12.Brain/Plasma Ratio / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.13.Log BB / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.14.Brain to Plasma Free Drug Concentration Ratio / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.15.Permeability Surface Area Product / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.16.Apparent Permeability / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.17.Brain Uptake Index / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.18.Unbound Brain Volume of Distribution / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.19.Brain Unbound Concentration / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.20.Brain Free Fraction / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.21.Drug-Delivery Nanosystems / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.22.Polymeric Nanoparticles / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.23.Liposomes / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.24.Solid Lipid Nanoparticles / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 10.25.Conclusions / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- References / Palazzo Claudio / Piel Geraldine / Evrard Brigitte / Karim Reatul -- 11.1.Introduction / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.2.Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, and Amyotrophic Lateral Sclerosis / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.2.1.Alzheimer's Disease / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.2.2.Parkinson's Disease / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.2.3.Huntington's Disease / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.2.4.Amyotrophic Lateral Sclerosis / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.3.Growth Factors as a Novel Therapy to Treat Neurodegenerative Diseases / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.4.In vivo Administration Routes of GFs to Reach the Brain / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.4.1.Invasive Administration Routes: Intracerebroventricular and Intraparenchymal Routes / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.4.2.Intrathecal Administration / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.4.3.Parenteral Administration / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.4.4.Intranasal Administration / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz --, and Contents note continued: 11.5.Nanotechnology-Based DDS Releasing Growth Factors for the Treatment of CNS Diseases / Rosa Maria Hernandez / Oihane Gartziandia / Manoli Igartua / Jose Luis Pedraz / Enara Herran -- 11.5.1.Polymeric Nanospheres / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.5.2.Liposomes and Lipidic Nanocarriers / Oihane Gartziandia / Enara Herran / Jose Luis Pedraz / Manoli Igartua / Rosa Maria Hernandez -- 11.5.3.Gene Therapy / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 11.6.Conclusions / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- References / Oihane Gartziandia / Enara Herran / Rosa Maria Hernandez / Manoli Igartua / Jose Luis Pedraz -- 12.1.Introduction / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.2.Electrospun Nanofibers / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.2.1.Introduction / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.2.2.Drug-Incorporating Techniques / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.2.3.Types of Drugs Released / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.2.4.Clinical Applications / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.3.Self-Assembled Nanofibers / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.3.1.Introduction / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.3.2.Self-Assembly Techniques / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.3.3.Bioactive Factor Delivery Strategies / Zhi Yuan Lin / Lara Yildirimer / Xin Zhao / Wenguo Cui -- 12.3.4.Types of Drugs Incorporated / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.3.5.Applications in Tissue Engineering / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.4.Nanofibers by Thermally Induced Phase Separation / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.4.1.Introduction / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.4.2.Parameters Influencing Phase Separation / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.4.3.Drug Incorporation Techniques / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.4.4.Types of Drugs Incorporated / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.4.5.Applications in Tissue Engineering / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.5.Other Nanofibers / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.5.1.Carbon Nanofibers / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.5.2.Aluminum Nanofibers / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.5.3.Titanium Nanofibers / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 12.6.Conclusions and Future Directions / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- Acknowledgments / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- References / Xin Zhao / Wenguo Cui / Zhi Yuan Lin / Lara Yildirimer -- 13.1.Introduction / Mandeep Singh / Simarjot Kaur Sandhu / Parneet K. Deol / Gaurav Sharma / Jatinder Vir Yakhmi / Indu Pal Kaur / Monika Yadav -- 13.1.1.Historical Perspectives / Indu Pal Kaur / Gaurav Sharma / Mandeep Singh / Jatinder Vir Yakhmi / Parneet K. Deol / Monika Yadav / Simarjot Kaur Sandhu -- 13.1.2.Limitations and a Word of Caution! / Indu Pal Kaur / Gaurav Sharma / Mandeep Singh / Jatinder Vir Yakhmi / Parneet K. Deol / Monika Yadav / Simarjot Kaur Sandhu -- 13.2.Gene Delivery / Indu Pal Kaur / Gaurav Sharma / Mandeep Singh / Jatinder Vir Yakhmi / Parneet K. Deol / Monika Yadav / Simarjot Kaur Sandhu -- 13.2.1.Barriers to Gene Delivery / Indu Pal Kaur / Gaurav Sharma / Mandeep Singh / Jatinder Vir Yakhmi / Parneet K. Deol / Monika Yadav / Simarjot Kaur Sandhu -- 13.2.2.Options for Gene Delivery / Indu Pal Kaur / Gaurav Sharma / Mandeep Singh / Jatinder Vir Yakhmi / Parneet K. Deol / Monika Yadav / Simarjot Kaur Sandhu -- 13.3.Clinical Trials in Gene Therapy / Indu Pal Kaur / Gaurav Sharma / Mandeep Singh / Jatinder Vir Yakhmi / Parneet K. Deol / Monika Yadav / Simarjot Kaur Sandhu -- 13.3.1.Cancer / Indu Pal Kaur / Gaurav Sharma / Mandeep Singh / Jatinder Vir Yakhmi / Parneet K. Deol / Monika Yadav / Simarjot Kaur Sandhu -- 13.3.2.Cardiovascular Disease / Indu Pal Kaur / Gaurav Sharma / Mandeep Singh / Jatinder Vir Yakhmi / Parneet K. Deol / Monika Yadav / Simarjot Kaur Sandhu -- 13.4.Conclusions and Future Perspectives / Simarjot Kaur Sandhu / Parneet K. Deol / Monika Yadav / Mandeep Singh / Indu Pal Kaur / Gaurav Sharma / Jatinder Vir Yakhmi -- References / Indu Pal Kaur / Gaurav Sharma / Mandeep Singh / Jatinder Vir Yakhmi / Parneet K. Deol / Monika Yadav / Simarjot Kaur Sandhu -- Abbreviations / Abolfazl Yazdanpanah / Zahra Rezvani / Arash Ramedani / Masoud Mozafari / Narendra Pal Singh Chauhan / Sina Mortarzadeh / Aleksandra Urbanska / Mazaher Gholipourmalekabadi -- 14.1.Introduction / Abolfazl Yazdanpanah / Zahra Rezvani / Arash Ramedani / Masoud Mozafari / Narendra Pal Singh Chauhan / Sina Mortarzadeh / Aleksandra Urbanska / Mazaher Gholipourmalekabadi -- 14.2.Oral Insulin Administration / Abolfazl Yazdanpanah / Zahra Rezvani / Arash Ramedani / Masoud Mozafari / Narendra Pal Singh Chauhan / Sina Mortarzadeh / Aleksandra Urbanska / Mazaher Gholipourmalekabadi -- 14.2.1.Polymeric NPs / Abolfazl Yazdanpanah / Zahra Rezvani / Arash Ramedani / Masoud Mozafari / Narendra Pal Singh Chauhan / Sina Mortarzadeh / Aleksandra Urbanska / Mazaher Gholipourmalekabadi -- 14.2.2.Solid Lipid NPs / Abolfazl Yazdanpanah / Zahra Rezvani / Arash Ramedani / Masoud Mozafari / Narendra Pal Singh Chauhan / Sina Mortarzadeh / Aleksandra Urbanska / Mazaher Gholipourmalekabadi -- 14.2.3.Ceramic NPs / Abolfazl Yazdanpanah / Zahra Rezvani / Arash Ramedani / Masoud Mozafari / Narendra Pal Singh Chauhan / Sina Mortarzadeh / Aleksandra Urbanska / Mazaher Gholipourmalekabadi -- 14.3.Conclusions / Sina Mortarzadeh / Aleksandra Urbanska / Masoud Mozafari / Narendra Pal Singh Chauhan / Zahra Rezvani / Arash Ramedani / Mazaher Gholipourmalekabadi / Abolfazl Yazdanpanah -- References / Abolfazl Yazdanpanah / Zahra Rezvani / Arash Ramedani / Masoud Mozafari / Narendra Pal Singh Chauhan / Sina Mortarzadeh / Aleksandra Urbanska / Mazaher Gholipourmalekabadi -- 15.1.Introduction / Ye Tian / Yujiao Sun / Shirui Mao / Georgios Kasparis / Xiaodan Wang -- 15.2.Basic Properties of Chitosan / Ye Tian / Yujiao Sun / Shirui Mao / Georgios Kasparis / Xiaodan Wang -- 15.2.1.Physicochemical and Biological Properties / Ye Tian / Yujiao Sun / Shirui Mao / Georgios Kasparis / Xiaodan Wang -- 15.2.2.Biodegradability / Ye Tian / Yujiao Sun / Shirui Mao / Georgios Kasparis / Xiaodan Wang -- 15.2.3.Immunoadjuvant and Nonallergenic Properties / Ye Tian / Yujiao Sun / Shirui Mao / Georgios Kasparis / Xiaodan Wang -- 15.3.Chemical Modifications of Chitosan / Ye Tian / Yujiao Sun / Shirui Mao / Georgios Kasparis / Xiaodan Wang -- 15.3.1.Hydrophilic Modification / Ye Tian / Yujiao Sun / Shirui Mao / Georgios Kasparis / Xiaodan Wang -- 15.3.2.Hydrophobic Modification / Ye Tian / Yujiao Sun / Xiaodan Wang / Georgios Kasparis / Shirui Mao -- 15.4.Chitosan-Based Nano-Formulations for Drug Delivery / Ye Tian / Yujiao Sun / Xiaodan Wang / Georgios Kasparis / Shirui Mao -- 15.4.1.Delivery of Poorly Soluble Small Molecules / Ye Tian / Yujiao Sun / Xiaodan Wang / Georgios Kasparis / Shirui Mao -- 15.4.2.Delivery of Proteins and Peptides / Yujiao Sun / Ye Tian / Xiaodan Wang / Shirui Mao / Georgios Kasparis -- 15.4.3.Delivery of Vaccines / Ye Tian / Yujiao Sun / Xiaodan Wang / Georgios Kasparis / Shirui Mao -- 15.4.4.Delivery of Genes / Ye Tian / Yujiao Sun / Georgios Kasparis / Xiaodan Wang / Shirui Mao -- 15.5.Chitosan-Based Nano-Formulations for Different Administration Routes / Yujiao Sun / Ye Tian / Xiaodan Wang / Shirui Mao / Georgios Kasparis -- 15.5.1.Intravenous Administration / Yujiao Sun / Ye Tian / Xiaodan Wang / Georgios Kasparis / Shirui Mao -- 15.5.2.Oral Administration / Ye Tian / Yujiao Sun / Xiaodan Wang / Georgios Kasparis / Shirui Mao -- 15.5.3.Intranasal Administration / Yujiao Sun / Ye Tian / Xiaodan Wang / Shirui Mao / Georgios Kasparis -- 15.5.4.Pulmonary Administration / Ye Tian / Yujiao Sun / Xiaodan Wang / Georgios Kasparis / Shirui Mao -- 15.5.5.Ocular Administration / Ye Tian / Yujiao Sun / Xiaodan Wang / Georgios Kasparis / Shirui Mao -- 15.5.6.Transdermal Administration / Shirui Mao / Ye Tian / Yujiao Sun / Xiaodan Wang / Georgios Kasparis -- 15.5.7.Buccal Administration / Georgios Kasparis / Xiaodan Wang / Yujiao Sun / Ye Tian / Shirui Mao -- 15.6.Chitosan and Its Derivatives for Site-Specific Targeted Drug Delivery / Ye Tian / Yujiao Sun / Xiaodan Wang / Georgios Kasparis / Shirui Mao -- 15.7.Future Opportunities and Challenges / Georgios Kasparis / Xiaodan Wang / Yujiao Sun / Ye Tian / Shirui Mao -- Acknowledgments / Yujiao Sun / Ye Tian / Xiaodan Wang / Georgios Kasparis / Shirui Mao -- References / Yujiao Sun / Ye Tian / Xiaodan Wang / Shirui Mao / Georgios Kasparis.
Subject(s)
ISBN
9780323428897
0323428894
Bibliography Note
Includes bibliographical references and index.
Source of Acquisition
Purchased with funds from the Margaret MacDonald Roeder Memorial Libraries Endowment for Engineering; 2016
Endowment Note
Margaret MacDonald Roeder Memorial Libraries Endowment for Engineering
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