Actions for Indole ring synthesis : from natural products to drug discovery
Indole ring synthesis : from natural products to drug discovery / Gordon Gribble
- Author
- Gribble, Gordon W.
- Published
- Chichester, West Sussex : Wiley, 2016.
- Physical Description
- 1 online resource
Access Online
- Contents
- Machine generated contents note: 1.Introduction -- 1.1.Preview -- 1.2.Indole-Containing Natural Products -- 1.3.Biological Activity of Indoles -- 1.4.Indole-Containing Pharmaceuticals -- 1.5.Indole-Containing Materials -- 1.6.Indole-Containing Ligands -- 1.7.Reviews of Indole-Ring Synthesis -- 1.7.1.General Reviews on Indole Ring Synthesis -- 1.7.2.Specialized Reviews -- 1.7.3.Name Reactions -- 1.7.4.Miscellaneous Reviews -- 1.7.5.Synthesis of Carbazoles, Carbolines, and Indolocarbazoles -- 1.7.6.Reviews of Indole Analogues 34 References -- pt. I Sigmatropic Rearrangements -- 2.Fischer Indole Synthesis -- 2.1.Preview -- 2.2.Methods -- 2.2.1.Traditional Methods -- 2.2.2.Metal-Catalyzed Methods -- 2.2.3.Solid-Phase Fischer Indolization Method -- 2.2.4.Other General Methods -- 2.2.5.Hydrazones -- 2.2.6.Other Variations of Fischer Indole Synthesis -- 2.3.Applications of Fischer Indolizations -- 2.3.1.Drug Targets -- 2.3.2.Natural Products -- 2.3.3.Materials -- 2.3.4.General -- References -- 3.Gassman Indole Synthesis -- 4.Bartoli Indole Synthesis -- 5.Thyagarajan Indole Synthesis -- 6.Julia Indole Synthesis -- 7.Miscellaneous Sigmatropic Rearrangements -- pt. II Nucleophilic Cyclization -- 8.Madelung Indole Synthesis -- 9.Wittig--Madelung Indole Synthesis -- 10.Jones--Schmid Indole Synthesis -- 11.Couture Indole Synthesis -- 12.Wender Indole Synthesis -- 13.Smith Indole Synthesis -- 14.Kihara Indole Synthesis -- 15.Nenitzescu 5-Hydroxyindole Synthesis -- 16.Engler-Kita Indole Synthesis -- 17.Bailey--Liebeskind--O'Shea Indoline--Indole Synthesis -- 18.Wright Indoline Synthesis -- 19.Saegusa Indole Synthesis -- 20.Ichikawa Indole Synthesis -- 21.Miscellaneous Nucleophilic Cyclizations that Form the Indole Ring -- 22.Sugasawa Indole Synthesis -- pt. III Electrophilic Cyclization -- 23.Bischler Indole Synthesis -- 24.The Nordlander Indole Synthesis -- 25.Nitrene Cyclization -- 26.Cadogan--Sundberg Indole Synthesis -- 27.Sundberg Indole Synthesis -- 28.Hemetsberger Indole Synthesis -- 29.Taber Indole Synthesis -- 30.Knochel Indole Synthesis -- 31.Tauber Carbazole Synthesis -- 32.Queguiner Azacarbazole Synthesis -- 33.Iwao Indole Synthesis -- 34.Hewson Indole Synthesis -- 35.Magnus Indole Synthesis -- 36.Feldman Indole Synthesis -- 37.Butin Indole Synthesis -- 38.Miscellaneous Electrophilic Cyclizations -- pt. IV Reductive Cyclization -- 39.Nenitzescu o,β-Dinitrostyrene Reductive Cyclization -- 40.Reissert Indole Synthesis -- 41.Leimgruber--Batcho Indole Synthesis -- 42.Pschorr--Hoppe Indole Synthesis -- 43.Makosza Indole Synthesis -- 44.Rawal Indole Synthesis -- 45.The Baeyer--Jackson Indole Synthesis and Miscellaneous Reductive Cyclization Indole Syntheses -- pt. V Oxidative Cyclization -- 46.Watanabe Indole Synthesis -- 47.Knolker Carbazole Synthesis -- 48.Miscellaneous Oxidative Cyclizations -- pt. VI Radical Cyclization -- 49.Fukuyama Indole Synthesis -- 50.Other Tin-Mediated Indole Syntheses -- 51.The Murphy Indole Synthesis -- 52.Miscellaneous Radical-Promoted Indole Syntheses -- 53.The Graebe--Ullmann Carbazole-Carboline Synthesis -- pt. VII Cycloaddition and Electrocyclization -- 54.Diels--Alder Cycloaddition -- 55.Plieninger Indole Synthesis -- 56.Photochemical Synthesis of Indoles and Carbazoles -- 57.Dipolar Cycloaddition, Anionic, and Electrocyclization Reactions -- pt. VIII Indoles from Pyrroles -- 58.Electrophilic Cyclization of Pyrrole -- 59.Palladium-Catalyzed Cyclization of Pyrroles -- 60.Cycloaddition Syntheses from Vinyl Pyrroles -- 61.Electrocyclization of Pyrroles -- 62.Indoles from Pyrrolo-2,3-Quinodimethanes -- 63.Indoles via Dehydrogenation of Pyrroles -- 64.Miscellaneous Indole Syntheses from Pyrroles -- 65.Indoles via Arynes -- pt. IX Indoles from Indolines -- 66.Indoline Dehydrogenation -- 67.Indolines to Indoles by Functionalized Elimination -- 68.Indolines from Oxindoles, Isatins, and Indoxyls -- pt. X Metal-Catalyzed Indole Synthesis -- 69.Copper-Catalyzed Indole Synthesis -- 70.Palladium-Catalyzed Indole Ring Synthesis: Hegedus -- 71.Palladium-Catalyzed Indole Ring Synthesis: Mori--Ban--Heck -- 72.Palladium-Catalyzed Indole Ring Synthesis: Aryl-Heck -- 73.Palladium-Catalyzed Indole Ring Synthesis: Oxidative Cyclization -- 74.Palladium-Catalyzed Indole Ring Synthesis: Watanabe--Cenini--Soderberg -- 75.Palladium-Catalyzed Indole Ring Synthesis: Yamanaka--Sakamoto--Sonogashira -- 76.Palladium-Catalyzed Indole Ring Synthesis: Larock -- 77.Palladium-Catalyzed Indole Ring Synthesis: Cacchi -- 78.Palladium-Catalyzed Indole Ring Synthesis: Buchwald--Hartwig -- 79.Palladium-Catalyzed Indole Ring Synthesis: Miscellaneous -- 80.Rhodium-Catalyzed Indole Ring Synthesis -- 81.Gold-Catalyzed Indole Ring Synthesis -- 82.Ruthenium-Catalyzed Indole Ring Synthesis -- 83.Platinum-Catalyzed Indole Ring Synthesis -- 84.Silver- and Zinc-Catalyzed Indole Ring Synthesis -- 85.Iron-, Iridium-, and Indium-Catalyzed Indole Ring Syntheses -- 86.Nickel-, Cobalt-, and Molybdenum-Catalyzed Indole Ring Syntheses -- 87.Mercury- and Chromium-Catalyzed Indole Ring Syntheses -- 88.Miscellaneous Metal-Catalyzed Indole Ring Syntheses -- pt. XI Miscellaneous -- 89.Miscellaneous Indole Ring Syntheses.
- Summary
- Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade - highlighted by the power of transition metal catalysis - this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal-catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.
- Subject(s)
- ISBN
- 0470512180 (cloth)
1118683056 (pdf)
1118683854 (epub)
1118695690
9780470512180 (cloth)
9781118683057 (pdf)
9781118683859 (epub)
9781118695692 - Bibliography Note
- Includes bibliographical references and index.
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