Design of hybrid molecules for drug development / edited by Michael Decker
- Published
- Oxford : Elsevier, 2017.
- Physical Description
- 1 online resource
- Additional Creators
- Decker, M. (Michael)
Access Online
- Contents
- Machine generated contents note: 1.Introduction / Michael Decker -- 2.Multitarget-Directed Antioxidants as Therapeutic Agents: Putting the Focus on the Oxidative Stress / Jose Marco-Contelles -- Abbreviations -- 2.1.Introduction -- 2.2.Melatonin Hybrids -- 2.3.Ferulic Acid Hybrids -- 2.4.Conclusions -- References -- 3.Towards Gaseous Mediator Hybrid Drugs / John F. Gilmer -- 3.1.Introduction: Gaseous Mediators NO, H2S, and CO -- 3.2.The Toolbox: Synthetic Donor Moieties for NO and H2S Release -- 3.3.NO and H2S Hybrid Drugs Candidates -- 3.4.Carbon Monoxide Donor Compounds, Design, and Hybrid Drugs -- 3.5.Overview, Challenges, and Concluding Remarks -- References -- 4.Designed Hybrid Compounds for Tropical Parasitic Diseases / Kelly Chibale -- 4.1.General Introduction -- 4.2.Major Tropical Parasitic Diseases -- 4.3.Hybrid Molecules for Tropical Parasitic Infections -- 4.4.Conclusions -- 4.5.Future Prospects -- References -- 5.Dual-Acting Compounds Acting as Receptor Ligands and Enzyme Inhibitors / Michael Decker -- 5.1.Introduction -- 5.2.Challenges -- 5.3.Approaches and Examples -- 5.4.Multifunctional Ligands for the Treatment of Pain -- 5.5.Multifunctional Ligands for the Treatment of CNS Diseases -- 5.6.Multitarget Compounds for the Treatment of Cardiovascular Diseases -- 5.7.Conclusion -- References -- 6.Multitarget Anti-Alzheimer Hybrid Compounds: Do They Work In Vivo? / Diego Munoz-Torrero -- List of Abbreviations -- 6.1.Multitarget Therapies Against Alzheimer's Disease -- 6.2.Pharmacophore Combination Approach: Pros, Cons, and Challenges of Anti-Alzheimer Hybrid Compounds -- 6.3.Evolution of Multitarget Anti-Alzheimer Drug Discovery -- 6.4.In Vivo Efficacy Studies With Multitarget Anti-Alzheimer Hybrid Compounds -- 6.5.Conclusions -- References -- 7.Anticancer Hybrids / Guozheng Huang -- 7.1.Introduction -- 7.2.Hybrid Drug Design for Cancer Treatment -- 7.3.Methods to Construct Anticancer Hybrids -- 7.4.Clinical Application of Hybrid Anticancer Drugs -- 7.5.Cancer Cell-Targeting Hybrids -- 7.6.Future Prospects -- Acknowledgement -- References -- 8.Molecular Hybridization: An Emerging Tool for the Design of Novel Therapeutics for Alzheimer's Disease / Liu He -- 8.1.Introduction -- 8.2.Molecular Hybridization and Pharmacophore Conjugation: Practical Methods for the Design of Multifunctional Drugs for AD -- 8.3.Summary -- References -- 9.Computational Methods in Multitarget Drug Discovery / Andrea Cavalli -- 9.1.Introduction -- 9.2.Methods to Identify Target Combinations -- 9.3.Computationally Driven Multitarget Hit Discovery -- 9.4.Computationally Driven Optimization of Multitarget Hits -- 9.5.Perspective and Oudook -- 9.6.Conclusions -- References -- 10.Medicinal Chemistry of Hybrids for Neurodegenerative Diseases / Maria Laura Bolognesi -- 10.1.Introduction -- 10.2.Design Strategies for Merged, Linked, and Fused Hybrids -- 10.3.Hybrids for Alzheimer's Disease -- 10.4.Hybrids for Prion Diseases -- 10.5.Conclusions -- References -- 11.Photoresponsive Hybrid Compounds / Michael Decker -- 11.1.Introduction -- 11.2.Light as an External Stimulus -- 11.3.Molecular Photoswitches -- 11.4.Design and Synthesis -- 11.5.Targets -- 11.6.Conclusion -- References.
- Summary
- Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.
- Subject(s)
- ISBN
- 9780081011188 (electronic bk.)
0081011180 (electronic bk.)
9780081010112
0081010117 - Bibliography Note
- Includes bibliographical references and index.
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