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Medicinal chemistry approaches to personalized medicine [electronic resource] / edited by Karen Lackey and Bruce D. Roth

Published
Weinheim, Germany : Wiley-VCH, [2014]
Physical Description
xxvii, 377 pages : illustrations (some color) ; 25 cm.
Additional Creators
Lackey, Karen and Roth, Bruce D.
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Contents
1. Medicinal Chemistry Approaches to Creating Targeted Medicines -- 2. Discovery of Predictive Biomarkers for Anticancer Drugs -- 3. Crizotinib -- 4 Discovery and Development of Vemurafenib: First-in-Class Inhibitor of Mutant BRAF for the Treatment of Cancer -- 5. Targeting Basal-Cell Carcinoma: Discovery and Development of Vismodegib (GDC-0449), a First-in-Class Inhibitor of the Hedgehog Pathway -- 6. G-Quadruplexes as Therapeutic Targets in Cancer -- 7. Identifying Actionable Targets in Cancer Patients -- 8. DNA Damage Repair Pathways and Synthetic Lethality -- 9. DNA Damage Repair Pathways and Synthetic Lethality -- 10. From Human Genetics to Drug Candidates: An Industrial Perspective on LRRK2 Inhibition as a Treatment for Parkinson's Disease -- 11. Therapeutic Potential of Kinases in Asthma -- 12. Developing Targeted PET Tracers in the Era of Personalized Medicine -- 13. Medicinal Chemistry in the Context of the Human Genome.
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ISBN
9783527333943 (Print ; alk. paper)
3527333940 (Print ; alk. paper)
9783527677283 (ePDF)
9783527677276 (ePub)
9783527677269 (Mobi)
9783527677252 (oBook)
Bibliography Note
Includes bibliographical references and index.
View MARC record | catkey: 20529255