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Student study guide/solutions manual for use with Biochemistry : the molecular basis of life, fifth edition / Trudy McKee, James R. McKee, Michael G. Sehorn

Author:
McKee, Trudy
Additional Titles:
Biochemistry
Published:
Oxford ; New York : Oxford University Press, [2012]
Copyright Date:
©2012
Edition:
5th ed.
Physical Description:
iii, 344 pages : illustrations ; 28 cm
Additional Creators:
McKee, James R. (James Robert), 1946-, Sehorn, Michael G., and McKee, Trudy

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Contents:
Machine generated contents note: 1.Biochemistry: An Introduction -- Life: It Is a Mystery! -- 1.1.What is Life? -- 1.2.Biomolecules -- Functional Groups of Organic Biomolecules -- Major Classes of Small Biomolecules -- 1.3.Is the Living Cell a Chemical Factory? -- Biochemical Reactions -- Energy -- Overview of Metabolism -- Biological Order -- 1.4.Systems Biology -- Emergence -- Robustness -- Modularity -- Biochemistry in the Lab -- An Introduction -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 2.Living Cells -- Our Bodies, Our Selves -- 2.1.Basic Themes -- Water -- Biological Membranes -- Self-Assembly -- Molecular Machines -- Macromolecular Crowding -- Signal Transduction -- 2.2.Structure of Prokaryotic Cells -- Cell Wall -- Plasma Membrane -- Cytoplasm -- Pili and Flagella -- 2.3.Structure of Eukaryotic Cells -- Plasma Membrane -- Endoplasmic Reticulum -- Golgi Apparatus -- Nucleus -- Vesicular Organelles -- Mitochondria -- Peroxisomes -- Plastids -- Cytoskeleton -- Ribosomes -- Biochemistry in Perspective -- Primary Cilia and Human Disease -- Biochemistry in the Lab -- Cell Technology -- Available Online: Biochemistry in Perspective -- Organelles and Human Disease -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 3.Water: The Matrix of Life -- Water, Water, Everywhere -- 3.1.Molecular Structure of Water -- 3.2.Noncovalent Bonding -- Ionic Interactions -- Hydrogen Bonds -- Van der Waals Forces -- 3.3.Thermal Properties of Water -- 3.4.Solvent Properties of Water -- Hydrophilic Molecules, Cell Water Structuring, and Sol-Gel Transitions -- Hydrophobic Molecules and the Hydrophobic Effect -- Amphipathic Molecules -- Osmotic Pressure -- 3.5.Ionization of Water -- Acids, Bases, and pH -- Buffers -- Physiological Buffers -- Biochemistry in Perspective -- Cell Volume Regulation and Metabolism -- Available Online: Biochemistry in Perspective -- Water, Abiotic Stress, and Compatible Solutes -- Biochemistry in the Lab -- Dialysis -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 4.Energy -- Energy and Life's Deep, Dark Secrets -- 4.1.Thermodynamics -- First Law of Thermodynamics -- Second Law of Thermodynamics -- 4.2.Free Energy -- Standard Free Energy Changes -- Coupled Reactions -- The Hydrophobic Effect Revisited -- 4.3.The Role of ATP -- Biochemistry in Perspective -- Nonequilibrium Thermodynamics and the Evolution of Life -- Available Online: Biochemistry in Perspective -- The Extremophiles: Organisms That Make a Living in Hostile Environments -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 5.Amino Acids, Peptides, and Proteins -- Spider Silk: A Biosteel Protein -- 5.1.Amino Acids -- Amino Acid Classes -- Biologically Active Amino Acids -- Modified Amino Acids in Proteins -- Amino Acid Stereoisomers -- Titration of Amino Acids -- Amino Acid Reactions -- 5.2.Peptides -- 5.3.Proteins -- Protein Structure -- The Folding Problem -- Fibrous Proteins -- Globular Proteins -- 5.4.Molecular Machines -- Motor Proteins -- Biochemistry in Perspective -- Spider Silk and Biomimetics -- Biochemistry in the Lab -- Protein Technology -- Available Online: Biochemistry in Perspective -- Protein Poisons -- Biochemistry in Perspective -- Protein Folding and Human Disease -- Biochemistry in Perspective -- Myosin: A Molecular Machine -- Biochemistry in the Lab -- Protein Sequence Analysis: The Edman Degradation -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 6.Enzymes -- Humans and Enzymes: A Brief History -- 6.1.Properties of Enzymes -- 6.2.Classification of Enzymes -- 6.3.Enzyme Kinetics -- Michaelis-Menten Kinetics -- Lineweaver-Burk Plots -- Multisubstrate Reactions -- Enzyme Inhibition -- Enzyme Kinetics, Metabolism, and Macromolecular Crowding -- 6.4.Catalysis -- Organic Reactions and the Transition State -- Catalytic Mechanisms -- The Roles of Amino Acids in Enzyme Catalysis -- The Role of Cofactors in Enzyme Catalysis -- Effects of Temperature and pH on Enzyme-Catalyzed Reactions -- Detailed Mechanisms of Enzyme Catalysis -- 6.5.Enzyme Regulation -- Genetic Control -- Covalent Modification -- Allosteric Regulation -- Compartmentation -- Biochemistry in Perspective -- Alcohol Dehydrogenase: A Tale of Two Species -- Available Online: Biochemistry in Perspective -- Enzymes and Clinical Medicine -- Biochemistry in Perspective -- Quantum Tunneling and Catalysis -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 7.Carbohydrates -- Sweet and Bitter Taste: The Roles of Sugar Molecules -- 7.1.Monosaccharides -- Monosaccharide Stereoisomers -- Cyclic Structure of Monosaccharides -- Reactions of Monosaccharides -- Important Monosaccharides -- Monosaccharide Derivatives -- 7.2.Disaccharides -- 7.3.Polysaccharides -- Homoglycans -- Heteroglycans -- 7.4.Glycoconjugates -- Proteoglycans -- Glycoproteins -- 7.5.The Sugar Code -- Lectins: Translators of the Sugar Code -- The Glycome -- Biochemistry in the Lab -- Glycomics -- Available Online: Biochemistry in Perspective -- Scurvy and Ascorbic Acid -- Biochemistry in Perspective -- Sweet Medicine -- Biochemistry in Perspective -- Conversion of Fischer Structures into Haworth Structures -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 8.Carbohydrate Metabolism -- Metabolism and Jet Engines -- 8.1.Glycolysis -- The Reactions of the Glycolytic Pathway -- The Fates of Pyruvate -- The Energetics of Glycolysis -- Regulation of Glycolysis -- 8.2.Gluconeogenesis -- Gluconeogenesis Reactions -- Gluconeogenesis Substrates -- Gluconeogenesis Regulation -- 8.3.The Pentose Phosphate Pathway -- 8.4.Metabolism of Other Important Sugars -- Fructose Metabolism -- 8.5.Glycogen Metabolism -- Glycogenesis -- Glycogenolysis -- Regulation of Glycogen Metabolism -- Biochemistry in Perspective -- Saccharomyces cerevisiae and the Crabtree Effect -- Biochemistry in Perspective Turbo Design Can Be Dangerous -- Available Online: Biochemistry in Perspective -- Fermentation: An Ancient Heritage -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 9.Aerobic Metabolism I: The Citric Acid Cycle -- Oxygen and Evolution: Chance and Necessity -- 9.1.Oxidation-Reduction Reactions -- Redox Coenzymes -- Aerobic Metabolism -- 9.2.Citric Acid Cycle -- Conversion of Pyruvate to Acetyl-CoA -- Reactions of the Citric Acid Cycle -- Fate of Carbon Atoms in the Citric Acid Cycle -- The Amphibolic Citric Acid Cycle -- Citric Acid Cycle Regulation -- The Citric Acid Cycle and Human Disease -- The Glyoxylate Cycle -- Biochemistry in Perspective -- The Evolutionary History of the Citric Acid Cycle -- Available Online: Biochemistry in Perspective -- Hans Krebs and the Citric Acid Cycle -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 10.Aerobic Metabolism II: Electron Transport and Oxidative Phosphorylation -- Oxygen: A Molecular Paradox -- 10.1.Electron Transport -- Electron Transport and Its Components -- Electron Transport: The Fluid-State and Solid-State Models -- Electron Transport Inhibitors -- 10.2.Oxidative Phosphorylation -- The Chemiosmotic Theory -- ATP Synthesis -- Control of Oxidative Phosphorylation -- The Complete Oxidation of Glucose -- Uncoupled Electron Transport -- 10.3.Oxygen, Cell Function, and Oxidative Stress -- Reactive Oxygen Species -- Antioxidant Enzyme Systems -- Antioxidant Molecules -- Biochemistry in Perspective -- Myocardial Infarct: Ischemia and Reperfusion -- Available Online: Biochemistry in Perspective -- Glucose-6-Phosphate Dehydrogenase Deficiency -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 11.Lipids and Membranes -- The Low-Fat Diet -- 11.1.Lipid Classes -- Fatty Acids -- The Eicosanoids -- Triacylglycerols -- Wax Esters -- Phospholipids -- Phospholipases -- Sphingolipids -- Sphingolipid Storage Diseases -- Isoprenoids -- Lipoproteins -- 11.2.Membranes -- Membrane Structure -- Membrane Function -- Biochemistry in Perspective -- Botulism and Membrane Fusion -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 12.Lipid Metabolism -- Abetalipoproteinemia -- 12.1.Fatty Acids, Triacylglycerols, and the Lipoprotein Pathways -- 12.2.Glyceroneogenesis and the TG Cycle -- Fatty Acid Degradation -- The Complete Oxidation of a Fatty Acid -- Fatty Acid Oxidation: Double Bonds and Odd Chains -- Fatty Acid Biosynthesis -- Regulation of Fatty Acid Metabolism in Mammals -- Lipoprotein Metabolism: The Endogenous Pathway -- 12.3.Membrane Lipid Metabolism -- Phospholipid Metabolism -- Sphingolipid Metabolism -- 12.4.Isoprenoid Metabolism -- Cholesterol Metabolism -- The Cholesterol Biosynthetic Pathway and Drug Therapy -- Biochemistry in Perspective -- Atherosclerosis -- Biochemistry in Perspective -- Biotransformation -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 13.Photosynthesis -- Climate Change, Renewable Energy, and Photosynthesis -- 13.1.Chlorophyll and Chloroplasts -- 13.2.Light -- 13.3.Light Reactions -- Photosystem II and Water Oxidation -- Photosystem I and NADPH Synthesis -- Photophosphorylation -- 13.4.The Light-Independent Reactions -- The Calvin Cycle -- Photorespiration -- Alternatives to C3 Metabolism -- 13.5.Regulation of Photosynthesis -- Light Control of Photosynthesis -- Control of Ribulose-1,5-Bisphosphate Carboxylase -- Biochemistry in Perspective -- Photosynthesis in the Deep -- Available Online: Biochemistry in Perspective -- Starch and Sucrose Metabolism -- Biochemistry in the Lab -- Photosynthetic Studies -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- and Contents note continued: 14.Nitrogen Metabolism I: Synthesis -- Nitrogen and the Gulf of Mexico Dead Zone -- 14.1.Nitrogen Fixation -- The Nitrogen Fixation Reaction -- Nitrogen Assimilation -- 14.2.Amino Acid Biosynthesis -- Amino Acid Metabolism Overview -- Reactions of Amino Groups -- Synthesis of the Amino Acids -- 14.3.Biosynthetic Reactions Involving Amino Acids -- One-Carbon Metabolism -- Glutathione -- Neurotransmitters -- Nucleotides -- Heme -- Biochemistry in Perspective -- Gasotransmitters -- Available Online: Biochemistry in Perspective -- The Amine Neurotransmitters -- Biochemistry in Perspective -- Parkinson's Disease and Dopamine -- Biochemistry in Perspective -- Heme and Chlorophyll Biosynthesis -- Biochemistry in Perspective -- The Essential Amino Acids -- Biochemistry in Perspective -- The Nucleotides: IMP Biosynthesis -- Biochemistry in Perspective -- Lead Poisoning -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 15.Nitrogen Metabolism II: Degradation -- Degradative Pathways and Human Disorders -- 15.1.Protein Turnover -- Ubiquitin Proteasomal System -- Autophagy-Lysosomal System -- 15.2.Amino Acid Catabolism -- Deamination -- Urea Synthesis -- Control of the Urea Cycle -- Catabolism of Amino Acid Carbon Skeletons -- 15.3.Neurotransmitter Degradation -- 15.4.Nucleotide Degradation -- Purine Catabolism -- Pyrimidine Catabolism -- Biochemistry in Perspective -- Disorders of Amino Acid Catabolism -- Available Online: Biochemistry in Perspective -- Hyperammonemia -- Biochemistry in Perspective -- Gout -- Biochemistry in Perspective -- Heme Biotransformation -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 16.Integration of Metabolism -- Hypertension and Uric Acid: A Diet Connection? -- 16.1.Overview of Metabolism -- 16.2.Hormones and Intercellular Communication -- Peptide Hormones -- Growth Factors -- Steroid and Thyroid Hormone Mechanisms -- 16.3.Metabolism in the Mammalian Body: Division of Labor -- Gastrointestinal Tract -- Liver -- Muscle -- Adipose Tissue -- Brain -- Kidney -- 16.4.The Feeding-Fasting Cycle -- The Feeding Phase -- The Fasting Phase -- Feeding Behavior -- Biochemistry in Perspective -- Diabetes Mellitus -- Biochemistry in Perspective -- Obesity and the Metabolic Syndrome -- Available Online: Biochemistry in Perspective -- Mammalian Hormones and the Hormone Cascade System -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 17.Nucleic Acids -- What Makes Us Human? -- 17.1.DNA -- DNA Structure: The Nature of Mutation -- DNA Structure: The Genetic Material -- DNA Structure: Variations on a Theme -- DNA Supercoiling -- Chromosomes and Chromatin -- Genome Structure -- 17.2.RNA -- Transfer RNA -- Ribosomal RNA -- Messenger RNA -- Noncoding RNA -- 17.3.Viruses -- Bacteriophage T4: A Viral Lifestyle -- Biochemistry in Perspective -- Eplgenetics and the Epigenome: Genetic Inheritance beyond DNA Base Sequences -- Biochemistry in the Lab -- Nucleic Acid Methods -- Biochemistry in Perspective -- Forensic Investigations -- Biochemistry in Perspective -- HIV Infection -- Available Online: Biochemistry in Perspective -- A Short History of DNA Research: The Early Years -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 18.Genetic Information -- DNA and Chimeras: A Biological and Legal Mystery -- 18.1.Genetic Information: Replication, Repair, and Recombination -- DNA Replication -- DNA Repair -- Direct Repairs -- DNA Recombination -- 18.2.Transcription -- Transcription in Prokaryotes -- RNAP and the Prokaryotic Transcription Process -- Transcription in Eukaryotes -- 18.3.Gene Expression -- Gene Expression in Prokaryotes -- Gene Expression in Eukaryotes -- Biochemistry in the Lab -- Genomics -- Biochemistry in Perspective -- Carcinogenesis -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions -- 19.Protein Synthesis -- MRSA: The Superbug -- 19.1.The Genetic Code -- Codon Usage Bias -- Codon-Anticodon Interactions -- The Aminoacyl-tRNA Synthetase Reaction -- 19.2.Protein Synthesis -- Prokaryotic Protein Synthesis -- Eukaryotic Protein Synthesis -- Biochemistry in Perspective -- Trapped Ribosomes: RNA to the Rescue! -- Biochemistry in Perspective -- Context-Dependent Coding Reassignment -- Biochemistry in the Lab -- Proteomics -- Available Online: Biochemistry in Perspective -- EF-Tu: A Motor Protein -- Chapter Summary -- Suggested Readings -- Key Words -- Review Questions -- Thought Questions.
Subject(s):
Genre(s):
ISBN:
9780199829606 (set)
0199829608 (set)
9780199730971 (pbk.)
0199730970 (pbk.)
View MARC record | catkey: 22865752