Actions for Targeting the DNA Damage Response for Anti-Cancer Therapy [electronic resource]

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Targeting the DNA Damage Response for Anti-Cancer Therapy [electronic resource] / edited by John Pollard, Nicola Curtin

Published
Cham : Springer International Publishing : Imprint: Humana Press, 2018.
Physical Description
IX, 401 pages 80 illustrations, 52 illustrations in color : online resource
Additional Creators
Pollard, John, Curtin, Nicola, and SpringerLink (Online service)
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Summary
Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR. In this book we will review a series of important topics that are of great interest to a broad range of academic, industrial and clinical researchers, including  the basic science of the DDR, its role in tumorigenesis and in dictating response to DNA damaging drugs and IR. Additionally, we will focus on the several proteins that have been targeted in attempts to provide drug candidates, each of which appear to have quite distinct profiles and could represent very different opportunities to provide patient benefit.
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ISBN
9783319758367
Digital File Characteristics
text file PDF
Part Of
Springer eBooks
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