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Metabolic evolution of Escherichia coli strains that produce organic acids [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2014.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Additional Creators
United States. Department of Energy. Office of Management, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids.
Report Numbers
E 1.99:8,871,489
8,871,489
Subject(s)
Note
Published through SciTech Connect.
10/28/2014.
"8,871,489"
"13/394,176"
Grabar, Tammy; Gong, Wei; Yocum, R.
Funding Information
EE0002878/001
View MARC record | catkey: 23493042