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Compositions and methods related to serotonin 5-HT1A receptors [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2012.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Additional Creators
Lawrence Berkeley National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Contemplated substituted arylpiperazinyl compounds, and most preferably .sup.18F-Mefway, exhibit desirable in vitro and in vivo binding characteristics to the 5-HT1A receptor. Among other advantageous parameters, contemplated compounds retain high binding affinity, display optimal lipophilicity, and are radiolabeled efficiently with .sup.18F-fluorine in a single step. Still further, contemplated compounds exhibit high target to non-target ratios in receptor-rich regions both in vitro and in vivo, and selected compounds can be effectively and sensitively displaced by serotonin, thus providing a quantitative tool for measuring 5-HT1A receptors and serotonin concentration changes in the living brain.
Report Numbers
E 1.99:re43,688
re43,688
Subject(s)
Note
Published through SciTech Connect.
09/25/2012.
"re43,688"
Mukherjee, Jogeshwar (Irvine, CA); Saigal, Neil (Fresno, CA); Saigal, legal representative, Harsh (Fresno, CA).
Funding Information
FG03-02ER63294
View MARC record | catkey: 23493508