Crystal structures of the components of the <i>Staphylococcus aureus</i> leukotoxin ED [electronic resource].
- Washington, D.C. : United States. Dept. of Energy, 2016. and Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
- Physical Description:
- pages 113-120 : digital, PDF file
- Additional Creators:
- Argonne National Laboratory, United States. Department of Energy, National Institutes of Health (U.S.), and United States. Department of Energy. Office of Scientific and Technical Information
- Restrictions on Access:
- Free-to-read Unrestricted online access
- Staphylococcal leukotoxins are a family of β-barrel, bicomponent, pore-forming toxins with membrane-damaging functions. These bacterial exotoxins share sequence and structural homology and target several host-cell types. Leukotoxin ED (LukED) is one of these bicomponent pore-forming toxins that<italic>Staphylococcus aureus</italic>produces in order to suppress the ability of the host to contain the infection. The recent delineation of the important role that LukED plays in<italic>S. aureus</italic>pathogenesis and the identification of its protein receptors, combined with its presence in<italic>S. aureus</italic>methicillin-resistant epidemic strains, establish this leukocidin as a possible target for the development of novel therapeutics. Here, the crystal structures of the water-soluble LukE and LukD components of LukED have been determined. Lastly, the two structures illustrate the tertiary-structural variability with respect to the other leukotoxins while retaining the conservation of the residues involved in the interaction of the protomers in the bipartite leukotoxin in the pore complex.
- Published through SciTech Connect., 01/01/2016., Acta Crystallographica. Section D. Structural Biology 72 1 ISSN 2059-7983; ACSDAD AM, and S. Nocadello; G. Minasov; L. Shuvalova; I. Dubrovska; E. Sabini; F. Bagnoli; G. Grandi; W. F. Anderson.
- Funding Information:
- AC02-06CH11357, HHSN272200700058C, and HHSN272201200026C
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