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Transferring biomarker into molecular probe [electronic resource] : Melanin nanoparticle as a naturally active platform for multimodality imaging

Published
Washington, D.C. : United States. Dept. of Energy. Office of Science, 2014.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description
pages 15,185-15,194 : digital, PDF file
Additional Creators
United States. Department of Energy. Office of Science and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Developing multifunctional and easily prepared nanoplatforms with integrated different modalities is highly challenging for molecular imaging. Here, we report the successful transfer of an important molecular target, melanin, into a novel multimodality imaging nanoplatform. Melanin is abundantly expressed in melanotic melanomas and thus has been actively studied as a target for melanoma imaging. In our work, the multifunctional biopolymer nanoplatform based on ultrasmall (<10 nm) water-soluble melanin nanoparticle (MNP) was developed and showed unique photoacoustic property and natural binding ability with metal ions (for example, 64Cu2+, Fe3+). Therefore, MNP can serve not only as a photoacoustic contrast agent, but also as a nanoplatform for positron emission tomography (PET) and magnetic resonance imaging (MRI). Traditional passive nanoplatforms require complicated and time-consuming processes for prebuilding reporting moieties or chemical modifications using active groups to integrate different contrast properties into one entity. In comparison, utilizing functional biomarker melanin can greatly simplify the building process. We further conjugated αvβ3 integrins, cyclic c(RGDfC) peptide, to MNPs to allow for U87MG tumor accumulation due to its targeting property combined with the enhanced permeability and retention (EPR) effect. As a result, the multimodal properties of MNPs demonstrate the high potential of endogenous materials with multifunctions as nanoplatforms for molecular theranostics and clinical translation.
Report Numbers
E 1.99:1345806
Subject(s)
Note
Published through SciTech Connect.
10/07/2014.
Journal of the American Chemical Society 136 43 ISSN 0002-7863 AM
Quli Fan; Kai Cheng; Xiang Hu; Xiaowei Ma; Ruiping Zhang; Min Yang; Xiaomei Lu; Lei Xing; Wei Huang; Sanjiv Sam Gambhir; Zhen Cheng.
Stanford Univ., Stanford, CA (United States)
Funding Information
SC0008397
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