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Red fluorescent zinc oxide nanoparticle [electronic resource] : A novel platform for cancer targeting

Published
Washington, D.C. : United States. Dept. of Energy. Office of Science, 2015.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description
pages 3,373-3,381 : digital, PDF file
Additional Creators
University of Wisconsin--Madison, United States. Department of Energy. Office of Science, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Multifunctional zinc oxide (ZnO) nanoparticles (NPs) with well-integrated multimodality imaging capacities have generated increasing research interest in the past decade. However, limited progress has been made in developing ZnO NP-based multimodality tumor-imaging agents. In this paper, we developed novel red fluorescent ZnO NPs and described the successful conjugation of 64Cu (t1/2 = 12.7 h) and TRC105, a chimeric monoclonal antibody against CD105, to these ZnO NPs via well-developed surface engineering procedures. The produced dual-modality ZnO NPs were readily applicable for positron emission tomography (PET) imaging and fluorescence imaging of the tumor vasculature. Their pharmacokinetics and tumor-targeting efficacy/specificity in mice bearing murine breast 4T1 tumor were thoroughly investigated. In conclusion, ZnO NPs with dual-modality imaging properties can serve as an attractive candidate for future cancer theranostics.
Report Numbers
E 1.99:1345171
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Note
Published through SciTech Connect.
01/21/2015.
ACS Applied Materials and Interfaces 7 5 ISSN 1944-8244 AM
Hao Hong; Fei Wang; Yin Zhang; Stephen A. Graves; Savo Bou Zein Eddine; Yunan Yang; Charles P. Theuer; Robert J. Nickles; Xudong Wang; Weibo Cai.
Funding Information
SC0008384
View MARC record | catkey: 23494112