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Lipid membrane-assisted condensation and assembly of amphiphilic Janus particles [electronic resource].

Published:
Washington, D.C. : United States. National Nuclear Security Administration, 2016.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description:
pages 9,151-9,157 : digital, PDF file
Additional Creators:
Sandia National Laboratories, United States. National Nuclear Security Administration, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary:
Amphiphilic Janus particles self-assemble into complex metastructures, but little is known about how their assembly might be modified by weak interactions with a nearby biological membrane surface. Here, we report an integrated experimental and molecular dynamics simulation study to investigate the self-assembly of amphiphilic Janus particles on a lipid membrane. We created an experimental system in which Janus particles are allowed to self-assemble in the same medium where zwitterionic lipids form giant unilamellar vesicles (GUVs). Janus particles spontaneously concentrated on the inner leaflet of the GUVs. They exhibited biased orientation and heterogeneous rotational dynamics as revealed by single particle rotational tracking. The combined experimental and simulation results show that Janus particles concentrate on the lipid membranes due to weak particle–lipid attraction, whereas the biased orientation of particles is driven predominantly by inter-particle interactions. Furthermore, this study demonstrates the potential of using lipid membranes to influence the self-assembly of Janus particles.
Report Numbers:
E 1.99:sand--2016-12074j
sand--2016-12074j
Subject(s):
Note:
Published through SciTech Connect.
01/01/2016.
"sand--2016-12074j"
"649523"
Soft Matter 12 45 ISSN 1744-683X; SMOABF AM
Mariah Chambers; Stewart Anthony Mallory; Heather Malone; Yuan Gao; Stephen M. Anthony; Yi Yi; Angelo Cacciuto; Yan Yu.
Funding Information:
AC04-94AL85000
View MARC record | catkey: 23498039