Actions for An open-source computational and data resource to analyze digital maps of immunopeptidomes [electronic resource].

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An open-source computational and data resource to analyze digital maps of immunopeptidomes [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2015.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description
e07,661 : digital, PDF file
Additional Creators
Pacific Northwest National Laboratory (U.S.), United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
We present a novel mass spectrometry-based high-throughput workflow and an open-source computational and data resource to reproducibly identify and quantify HLA-associated peptides. Collectively, the resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra, and the analysis of quantitative digital maps of HLA peptidomes generated from a range of biological sources by SWATH mass spectrometry (MS). This study represents the first community-based effort to develop a robust platform for the reproducible and quantitative measurement of the entire repertoire of peptides presented by HLA molecules, an essential step towards the design of efficient immunotherapies.
Report Numbers
E 1.99:1211538
Subject(s)
Note
Published through SciTech Connect.
07/08/2015.
eLife 4 ISSN 2050-084X AM
Caron, Etienne; Espona, Lucia; Kowalewski, Daniel; Schuster, Heiko; Ternette, Nicola; Alpízar, Adán; Schittenhelm, Ralf; Ramarathinam, Sri; Lindestam Arlehamn, Cecilia; Chiek Koh, Ching; Gillet, Ludovic; Rabsteyn, Armin; Navarro, Pedro; Kim, Sangtae; Lam, Henry; Sturm, Theo; Marcilla, Miguel; Sette, Alessandro; Campbell, David; Deutsch, Eric; Moritz, Robert; Purcell, Anthony; Rammensee, Hans; Stevanovic, Stefan; Aebersold, Ruedi.
Funding Information
1022509 and 1085017
HHSN272201200010C and HHSN272200900044C
ERC-2008-AdG_20080422
3100A0-688 107679
AC05-76RL01830
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