Increased inflammation in sanctuary sites may explain viral blips in HIV infection [electronic resource].
- Washington, D.C. : United States. Dept. of Energy, 2016. and Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
- Physical Description:
- 153-166 : digital, PDF file
- Additional Creators:
- Los Alamos National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
- Here, combined antiretroviral therapy (cART) suppress HIV-1 viral replication, such that viral load in plasma remains below the limit of detection in standard assays. However, intermittent episodes of transient viremia (blips) occur in a set of HIV-patients. Given that follicular hyperplasia occurs during lymphoid inflammation as a normal response to infection, it is hypothesised that when the diameter of the lymph node follicle (LNF) increases and crosses a critical size, a viral blip occurs due to cryptic viremia. To study this hypothesis, a theoretical analysis of a mathematical model is performed to find the conditions for virus suppression in all compartments and different scenarios of LNF size changes are simulated. According to the analysis, blips with duration of around 30 days arise when the diameter rise rate is between 0.02 and 0.03 days<sup>–1</sup>. Moreover, the final diameter of the site is directly related to the steady states of the virus load after the occurrence of a blip. When the value of R<sub>0</sub> is around 2.1, to have a steady-state below the limit of detection after the viral blip, the maximum final diameters should be greater than 0.7 mm so that there is a relative loss of connection between compartments.
- Published through SciTech Connect., 08/01/2016., "la-ur-16-20164", IET Systems Biology ISSN 1751-8849 AM, and Michael J. Piovoso; E. Fabian Cardozo; Ryan Zurakowski.
- Funding Information:
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