Actions for Construction and Evaluation of Novel Rhesus Monkey Adenovirus Vaccine Vectors [electronic resource].

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Construction and Evaluation of Novel Rhesus Monkey Adenovirus Vaccine Vectors [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2014.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description
pages 1,512-1,522 : digital, PDF file
Additional Creators
Los Alamos National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Adenovirus vectors are widely used as vaccine candidates for a variety of pathogens, including HIV-1. To date, human and chimpanzee adenoviruses have been explored in detail as vaccine vectors. Furthermore, the phylogeny of human and chimpanzee adenoviruses is overlapping, and preexisting humoral and cellular immunity to both are exhibited in human populations worldwide. More distantly related adenoviruses may therefore offer advantages as vaccine vectors. We describe the primary isolation and vectorization of three novel adenoviruses from rhesus monkeys. The seroprevalence of these novel rhesus monkey adenovirus vectors was extremely low in sub-Saharan Africa human populations, and these vectors proved to have immunogenicity comparable to that of human and chimpanzee adenovirus vaccine vectors in mice. These rhesus monkey adenoviruses phylogenetically clustered with the poorly described adenovirus species G and robustly stimulated innate immune responses. These novel adenoviruses represent a new class of candidate vaccine vectors.
Report Numbers
E 1.99:la-ur--14-28201
la-ur--14-28201
Subject(s)
Note
Published through SciTech Connect.
11/19/2014.
"la-ur--14-28201"
Journal of Virology 89 3 ISSN 0022-538X AM
Peter Abbink; Lori F. Maxfield; David Ng'ang'a; Erica N. Borducchi; M. Justin Iampietro; Christine A. Bricault; Jeffrey E. Teigler; Stephen Blackmore; Lily Parenteau; Kshitij Wagh; Scott A. Handley; Guoyan Zhao; Herbert W. Virgin; Korber, Bette [Los Alamos National Laboratory]; Dan H. Barouch.
Funding Information
AC52-06NA25396
View MARC record | catkey: 23498689