Spatial Distributions of Guest Molecule and Hydration Level in Dendrimer-Based Guest–Host Complex [electronic resource].
- Washington, D.C. : United States. Dept. of Energy. Office of Basic Energy Sciences, 2016.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
- Physical Description:
- pages 1,004-1,008 : digital, PDF file
- Additional Creators:
- Oak Ridge National Laboratory
United States. Department of Energy. Office of Basic Energy Sciences
China. Office of the Government of the People's Republic of China
United States. Department of Energy. Office of Scientific and Technical Information
- Using the electrostatic complex of G4 poly(amidoamine) (PAMAM) dendrimer with an amphiphilic surfactant as a model system, contrast variation small angle neutron scattering (SANS) is implemented to resolve the key structural characteristics of dendrimer-based guest–host system. Quantifications of the radial distributions of the scattering length density and the hydration level within the complex molecule reveal that the surfactant is embedded in the peripheral region of dendrimer and the steric crowding in this region increases the backfolding of the dendritic segments, thereby reducing the hydration level throughout the complex molecule. Here, the insights into the spatial location of the guest molecules as well as the perturbations of dendrimer conformation and hydration level deduced here are crucial for the delicate design of dendrimer-based guest–host system for biomedical applications.
- Published through SciTech Connect.
ACS Macro Letters 5 9 ISSN 2161-1653 AM
Chih-Ying Liu; Hsin-Lung Chen; Changwoo Do; Kunlun Hong.
- Funding Information:
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