Magnetic relaxometry as applied to sensitive cancer detection and localization [electronic resource].
- Washington, D.C. : United States. Dept. of Energy, 2015.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
- Physical Description:
- pages 445-455 : digital, PDF file
- Additional Creators:
- Los Alamos National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
- Restrictions on Access:
- Free-to-read Unrestricted online access
Here we describe superparamagnetic relaxometry (SPMR), a technology that utilizes highly sensitive magnetic sensors and superparamagnetic nanoparticles for cancer detection. Using SPMR, we sensitively and specifically detect nanoparticles conjugated to biomarkers for various types of cancer. SPMR offers high contrast
In SPMR measurements, a brief magnetizing pulse is used to align superparamagnetic nanoparticles of a discrete size. Following the pulse, an array of superconducting quantum interference detectors (SQUID) sensors detect the decaying magnetization field. NP size is chosen so that, when bound, the induced field decays in seconds. They are functionalized with specific biomarkers and incubated with cancer cells
As a result, superparamagnetic NPs developed here have small size dispersion. Cell incubation studies measure specificity for different cell lines and antibodies with very high contrast.
- Report Numbers:
- E 1.99:la-ur--15-21938
- Other Subject(s):
- Published through SciTech Connect.
Biomedizinische Technik 60 5 ISSN 0013-5585 AM
De Haro, Leyma; Karaulanov, Todor; Vreeland, Erika; Anderson, Bill; Hathaway, Helen; Huber, Dale; Matlashov, Andrei; Nettles, Christopher; Price, Andrew; Monson, Todd; Flynn, Edward.
- Funding Information: