Actions for Quantifying Carbon-14 for Biology Using Cavity Ring-Down Spectroscopy [electronic resource].

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Quantifying Carbon-14 for Biology Using Cavity Ring-Down Spectroscopy [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2016.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description
pages 8,714-8,719 : digital, PDF file
Additional Creators
Lawrence Berkeley National Laboratory, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
A cavity ring-down spectroscopy (CRDS) instrument was developed using mature, robust hardware for the measurement of carbon-14 in biological studies. The system was characterized using carbon-14 elevated glucose samples and returned a linear response up to 387 times contemporary carbon-14 concentrations. Carbon-14 free and contemporary carbon-14 samples with varying carbon-13 concentrations were used to assess the method detection limit of approximately one-third contemporary carbon-14 levels. Sources of inaccuracies are presented and discussed, and the capability to measure carbon-14 in biological samples is demonstrated by comparing pharmacokinetics from carbon-14 dosed guinea pigs analyzed by both CRDS and accelerator mass spectrometry. Here, the CRDS approach presented affords easy access to powerful carbon-14 tracer techniques that can characterize complex biochemical systems.
Report Numbers
E 1.99:llnl-jrnl--693042
llnl-jrnl--693042
Subject(s)
Note
Published through SciTech Connect.
07/26/2016.
"llnl-jrnl--693042"
Analytical Chemistry 88 17 ISSN 0003-2700 AM
A. Daniel McCartt; Ted J. Ognibene; Graham Bench; Kenneth W. Turteltaub.
Funding Information
AC52-07NA27344
View MARC record | catkey: 23499359