Structural and mechanical properties of cardiolipin lipid bilayers determined using neutron spin echo, small angle neutron and X-ray scattering, and molecular dynamics simulations [electronic resource].

Published: Washington, D.C. : United States. Dept. of Energy. Office of Basic Energy Sciences, 2014.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description: pages 130-138 : digital, PDF file
Additional Creators: Oak Ridge National Laboratory, United States. Department of Energy. Office of Basic Energy Sciences, National Science Foundation (U.S.), National Institutes of Health (U.S.), and United States. Department of Energy. Office of Scientific and Technical Information

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Summary

We report that the detailed structural and mechanical properties of a tetraoleoyl cardiolipin (TOCL) bilayer were determined using neutron spin echo (NSE) spectroscopy, small angle neutron and X-ray scattering (SANS and SAXS, respectively), and molecular dynamics (MD) simulations. We used MD simulations to develop a scattering density profile (SDP) model, which was then utilized to jointly refine SANS and SAXS data. In addition to commonly reported lipid bilayer structural parameters, component distributions were obtained, including the volume probability, electron density and neutron scattering length density.

Report Numbers

E 1.99:1286806

Subject(s)

Note

Published through SciTech Connect.
10/29/2014.
Soft Matter 11 1 ISSN 1744-683X; SMOABF AM
Jianjun Pan; Xiaolin Cheng; Melissa Sharp; Chian-Sing Ho; Nawal Khadka; John Katsaras.

Funding Information

AC05-00OR22725
DMR-1332208
AC02-05CH11231
AC05-00OR2275

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