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High throughput screening of ligand binding to macromolecules using high resolution powder diffraction [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2006.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Additional Creators
United States. Department of Energy and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
A process is provided for the high throughput screening of binding of ligands to macromolecules using high resolution powder diffraction data including producing a first sample slurry of a selected polycrystalline macromolecule material and a solvent, producing a second sample slurry of a selected polycrystalline macromolecule material, one or more ligands and the solvent, obtaining a high resolution powder diffraction pattern on each of said first sample slurry and the second sample slurry, and, comparing the high resolution powder diffraction pattern of the first sample slurry and the high resolution powder diffraction pattern of the second sample slurry whereby a difference in the high resolution powder diffraction patterns of the first sample slurry and the second sample slurry provides a positive indication for the formation of a complex between the selected polycrystalline macromolecule material and at least one of the one or more ligands.
Report Numbers
E 1.99:7,130,747
7,130,747
Subject(s)
Note
Published through SciTech Connect.
10/31/2006.
"7,130,747"
"09/871,527"
Von Dreele, Robert; D'Amico, Kevin.
Los Alamos National Security, LLC, Los Alamos, NM (United States)
Funding Information
W-7405-ENG-36
View MARC record | catkey: 23501168