Service interruption: Realtime availability, "I Want It," and My Account will be briefly offline on 8/18/22 from 1-1:30pm.

Export to Refworks Export to EndNote Email
Report an Issue

An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival [electronic resource].

Published:
Washington, D.C. : United States. Dept. of Energy. Office of Science, 2014.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description:
pages 4,011-4,025 : digital, PDF file
Additional Creators:
Lawrence Berkeley National Laboratory, United States. Department of Energy. Office of Science, and United States. Department of Energy. Office of Scientific and Technical Information
Access Online

Availability

I Want It

Finding items...

Restrictions on Access:
Free-to-read Unrestricted online access
Summary:
The concept that a breast cancer patient's menstrual stage at the time of tumor surgery influences risk of metastases remains controversial. The scarcity of comprehensive molecular studies of menstrual stage-dependent fluctuations in the breast provides little insight. To gain a deeper understanding of the biological changes in mammary tissue and blood during the menstrual cycle and to determine the influence of environmental exposures, such as low-dose ionizing radiation (LDIR), we used the mouse to characterize estrous-cycle variations in mammary gene transcripts by RNA-sequencing, peripheral white blood cell (WBC) counts and plasma cytokine levels. We identified an estrous-variable and hormone-dependent gene cluster enriched for Type-1 interferon genes. Cox regression identified a 117-gene signature of interferon-associated genes, which correlated with lower frequencies of metastasis in breast cancer patients. LDIR (10cGy) exposure had no detectable effect on mammary transcripts. However, peripheral WBC counts varied across the estrous cycle and LDIR exposure reduced lymphocyte counts and cytokine levels in tumor-susceptible mice. Our finding of variations in mammary Type-1 interferon and immune functions across the estrous cycle provides a mechanism by which timing of breast tumor surgery during the menstrual cycle may have clinical relevance to a patient's risk for distant metastases.
Report Numbers:
E 1.99:1407216
Subject(s):
Other Subject(s):
Note:
Published through SciTech Connect.
06/30/2014.
"ark:/13030/qt2p84g9f0"
Oncotarget 5 12 ISSN 1949-2553 AM
Antoine M. Snijders; Sasha Langley; Jian-Hua Mao; Sandhya Bhatnagar; Kathleen A. Bjornstad; Chris J. Rosen; Alvin Lo; Yurong Huang; Eleanor A. Blakely; Gary H. Karpen; Mina J. Bissell; Andrew J. Wyrobek.
Funding Information:
AC02-05CH11231
View MARC record | catkey: 23501177