Neutrons and the structural biology of second messenger signaling and regulation [electronic resource].
- Washington, D.C. : United States. Dept. of Energy, 2004.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
- Physical Description:
- 20 pages : digital, PDF file
- Additional Creators:
- Los Alamos National Laboratory
United States. Department of Energy
United States. Department of Energy. Office of Scientific and Technical Information
- Neutron contrast variation is a powerful technique for studying biomolecular complexes and the conformational flexibility that is inherent in bio-molecular signaling and regulation. We use this technique to study intra-cellular signaling and regulatory mechanisms mediated by second messengers such as calcium and cyclic nucleotides. Our recent results on the multifunctional, multi-subunit cyclic nucleotide-dependent protein kinases as well as kinases that play a role in regulating muscle mechanics will be presented. From this work we see common mechanistic themes in kinase activation as well as distinctive attributes that provide for specificity and functional diversity in this important class of enzymes that catalyze the most common type of reversible protein modification used to modulate protein function.
- Published through SciTech Connect.
Submitted to: 227th ACS national meeting, March 28, 2004.
Trewhella, J. (Jill).
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