Machine generated contents note: 1.Introduction -- 1.1.Building on the Legacy of Russell and Burch (1959/1992) -- 1.2.Four Movements to the Argument -- 1.3.Full Disclosure -- References -- 2.Concept Fatigue with the Three R's -- 2.1.The Original Work by Russell and Burch (1959/1992) in Context -- 2.1.1.On the Removal of Inhumanity -- 2.1.2.Humane Versus Speciesist -- 2.1.3.The Actual Definitions -- 2.2.Changing Perspectives on the Use of Animals -- 2.2.1.No Magic Dust -- 2.2.2.For the Animal's Sake -- 2.2.3.The Monkey Eye-Movement Paradigm Then and Now -- References -- 3.A Mismatch Between Micro-motives and Macro-behavior -- 3.1.Analyzing Aggregate Behavior -- 3.1.1.Three Classic Examples of Micro-Macro Conflict -- 3.1.2.Applying the Micro-Macro Analysis to Animal Research -- 3.2.The Principles of Reasonable Experimental Inquiry -- 3.2.1.On the Valuation of Research -- 3.2.2.The Preferred Animal Model -- 3.2.3.New Definitions -- References -- 4.The Monkey Question -- 4.1.A Critique of Arguments -- 4.1.1.The Past Is Not Always a Good Model for the Future -- 4.1.2.Misleading Claims of Necessity -- 4.1.3.An Erroneous Preference for Nonhuman Primates -- 4.1.4.A Prejudice Against Replacement with Other Animals -- 4.2.Examples of (Missed) Replacement Opportunities -- 4.2.1.Real-Time Control of a Robot Arm -- 4.2.2.Perceptual Decision-Making -- 4.2.3.Cognitive Mechanisms of Cocaine Addiction -- References -- 5.Toward Reasonable Experimental Inquiry -- 5.1.Replacement as the Critical R -- 5.1.1.Eyes Open to Opportunity Costs -- 5.1.2.Real-World Barriers to Replacement -- 5.1.3.A Shift in Agency -- 5.2.Practical Wisdom, Informed and Integrative -- 5.2.1.Open Science -- 5.2.2.Big Science -- 5.2.3.Free Thought and Coordinated Action -- 5.3.The Sleep of Reason Produces Monsters -- References.
