Actions for Formation of stable submicron peptide or protein particles by thin film freezing [electronic resource].

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Formation of stable submicron peptide or protein particles by thin film freezing [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2017.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Additional Creators
University of Texas at Austin, United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm.sup.-1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30.degree. C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm.sup.-1.
Report Numbers
E 1.99:9,622,974
9,622,974
Subject(s)
Note
Published through SciTech Connect.
04/18/2017.
"9,622,974"
"14/603,211"
Keith P. Johnston; Joshua Engstrom; Robert O. Williams, III.
Funding Information
FG02-04ER15549
View MARC record | catkey: 24043735