Actions for Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements [electronic resource] : what can it add and how far can it go?

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Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements [electronic resource] : what can it add and how far can it go?

Published
Washington, D.C. : United States. Dept. of Energy, 2016.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description
pages 81-98 : digital, PDF file
Additional Creators
Pacific Northwest National Laboratory (U.S.), United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Here, measuring the exposome remains a challenge due to the range and number of anthropogenic molecules that are encountered in our daily lives, as well as the complex systemic responses to these exposures. One option for improving the coverage, dynamic range and throughput of measurements is to incorporate ion mobility spectrometry (IMS) into current mass spectrometry (MS)-based analytical methods. In this perspective, we briefly review the state-of-the-art in measuring the exposome, and discuss the potential use for IMS-MS and the physico-chemical property of collisional cross section in both exposure assessment and molecular identification.
Report Numbers
E 1.99:pnnl-sa--121158
pnnl-sa--121158
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Note
Published through SciTech Connect.
12/06/2016.
"pnnl-sa--121158"
"48246"
Bioanalysis 9 1 ISSN 1757-6180 AM
Thomas O. Metz; Erin S. Baker; Emma L. Schymanski; Ryan S. Renslow; Dennis G. Thomas; Tim J. Causon; Ian K. Webb; Stephan Hann; Richard D. Smith; Justin G. Teeguarden.
Funding Information
AC05-76RL01830
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