Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and <i>in vivo</i> photoacoustic imaging [electronic resource].
- Washington, D.C. : United States. Dept. of Energy. Office of Basic Energy Sciences, 2015. and Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
- Physical Description:
- pages 3,731-3,737 : digital, PDF file
- Additional Creators:
- United States. Department of Energy. Office of Basic Energy Sciences and United States. Department of Energy. Office of Scientific and Technical Information
- Restrictions on Access:
- Free-to-read Unrestricted online access
- Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here in this paper we report –250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and with high sensitivity <i>via</i> photoacoustic imaging. The porphyrinoid macrocycles used in the present study are non-aromatic in the absence of the uranyl cation, but aromatic after cation complexation. We solubilized both the freebase and metalated forms of the macrocycles in poly(lactic-co-glycolic acid) and found a peak in the photoacoustic spectrum at 910 nm excitation in the case of the uranyl complex. The signal was stable for at least 15 minutes and allowed detection of uranium concentrations down to 6.2 ppb (5.7 nM) <i>in vitro</i> and 0.57 ppm (19 fCi; 0.52 μM) <i>in vivo</i>. Furthermore, to the best of our knowledge, this is the first report of a nanoparticle that detects an actinide cation via photoacoustic imaging.
- Published through SciTech Connect., 04/01/2015., Analyst 140 11 ISSN 0003-2654; ANALAO AM, I-Ting Ho; Jonathan L. Sessler; Sanjiv Sam Gambhir; Jesse V. Jokerst., and Univ. of Texas, Austin, TX (United States)
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