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Triazine-based sequence-defined polymers with side-chain diversity and backbone-backbone interaction motifs [electronic resource].

Published
Washington, D.C. : United States. Dept. of Energy, 2016.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description
pages 3,925-3,930 : digital, PDF file
Additional Creators
Pacific Northwest National Laboratory (U.S.), United States. Department of Energy, and United States. Department of Energy. Office of Scientific and Technical Information
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Summary
Sequence control in polymers, well-known in nature, encodes structure and functionality. Here we introduce a new architecture, based on the nucleophilic aromatic substitution chemistry of cyanuric chloride, that creates a new class of sequence defined polymers dubbed "TZPs". Proof of concept is demonstrated with two synthesized hexamers, having neutral and ionizable side chains. Molecular dynamics simulations show backbone-backbone interactions, including H-bonding motifs and pi-pi interactions. This architecture is arguably biomimetic while differing from sequence defined polymers having peptide bonds. Furthermore, the synthetic methodology supports the structural diversity of side chains known in peptides, as well as backbone-backbone hydrogen bonding motifs, and will thus thus enable new macromolecules and materials with useful functions.
Report Numbers
E 1.99:pnnl-sa--114408
pnnl-sa--114408
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Note
Published through SciTech Connect.
02/10/2016.
"pnnl-sa--114408"
Angewandte Chemie (International Edition) 55 12 ISSN 1433-7851 AM
Jay W. Grate; Kai -For Mo; Michael D. Daily.
Funding Information
AC05-76RL01830
View MARC record | catkey: 24057025