Early stratospheric science, chlorofluorocarbons, and the emergence of environmental concern -- Setting the stage: national action and early international efforts, 1970-1980 -- The search for knowledge-based resolution: science and scientific assessment, 1976-1985 -- Negotiations and strategy, 1980-1987 -- Eliminating chlorofluorocarbons: science, assessment, and responses, 1986-1988 -- Industry strategy and technical innovation, 1987-1992 -- Building an adaptive regime: the protocol evolving, 1989-1999 -- The theoretical and practical significance of the ozone regime.