Actions for Nanoporous Gold as a Neural Interface Coating [electronic resource] : Effects of Topography, Surface Chemistry, and Feature Size

Email RIS file
Bookmark
Report an Issue

Nanoporous Gold as a Neural Interface Coating [electronic resource] : Effects of Topography, Surface Chemistry, and Feature Size

Published
Washington, D.C. : United States. Dept. of Energy, 2015.
Oak Ridge, Tenn. : Distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy
Physical Description
pages 7,093-7,100 : digital, PDF file
Additional Creators
United States. Department of Energy and United States. Department of Energy. Office of Scientific and Technical Information
Access Online

Availability

I Want It
I Want It

Finding items...

Restrictions on Access
Free-to-read Unrestricted online access
Summary
We report that designing neural interfaces that maintain close physical coupling of neurons to an electrode surface remains a major challenge for both implantable and in vitro neural recording electrode arrays. Typically, low-impedance nanostructured electrode coatings rely on chemical cues from pharmaceuticals or surface-immobilized peptides to suppress glial scar tissue formation over the electrode surface (astrogliosis), which is an obstacle to reliable neuron–electrode coupling. Nanoporous gold (np-Au), produced by an alloy corrosion process, is a promising candidate to reduce astrogliosis solely through topography by taking advantage of its tunable length scale. In the present in vitro study on np-Au’s interaction with cortical neuron–glia co-cultures, we demonstrate that the nanostructure of np-Au achieves close physical coupling of neurons by maintaining a high neuron-to-astrocyte surface coverage ratio. Atomic layer deposition-based surface modification was employed to decouple the effect of morphology from surface chemistry. Additionally, length scale effects were systematically studied by controlling the characteristic feature size of np-Au through variations in the dealloying conditions. In conclusion, our results show that np-Au nanotopography, not surface chemistry, reduces astrocyte surface coverage while maintaining high neuronal coverage and may enhance neuron–electrode coupling through nanostructure-mediated suppression of scar tissue formation.
Report Numbers
E 1.99:1254148
Subject(s)
Other Subject(s)
Note
Published through SciTech Connect.
02/23/2015.
ACS Applied Materials and Interfaces 7 13 ISSN 1944-8244 AM
Christopher A. R. Chapman; Hao Chen; Marianna Stamou; Juergen Biener; Monika M. Biener; Pamela J. Lein; Erkin Seker.
Univ. of California, Davis, CA (United State
Funding Information
AC52-07NA27344
12-LR- 237197
DGE-1148897
T32-GM008799
U54 NS079202
View MARC record | catkey: 24479874