Advances in immunology. Volume 129 / edited by Frederick Alt
- Amsterdam : Academic Press, 2016.
- Physical Description:
- 1 online resource
- Additional Creators:
- Alt, Frederick W.
- Machine generated contents note: 1.Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules: A New Hypothesis for Autoimmune Diseases / Hisashi Arase -- 1.Introduction -- 2.Transport of ER-Misfolded Proteins to the Cell Surface by MHC Class II Molecules -- 3.Function of Protein Antigens Presented by MHC Class II Molecules -- 4.Misfolded Proteins Presented on MHC Class II Molecules Are Targets for Autoantibodies in Autoimmune Diseases -- 5.Susceptibility to Autoimmune Diseases Is Associated with the Affinity of Misfolded Proteins for MHC Class II Molecules -- 6.Involvement of Misfolded Protein-MHC Class II Molecule Complexes in Autoantibody-Mediated Pathogenicity -- 7.Misfolded Cellular Proteins Rescued from Degradation by MHC Class II Molecules May Abrogate Immune Tolerance -- 8.Misfolded Proteins Presented on MHC Class II Molecules as a Therapeutic Target for Autoimmune Diseases -- 9.Concluding Remarks -- Acknowledgments -- References -- 2.Mechanism of Diapedesis: Importance of the Transcellular Route / Marie-Dominique Filippi -- 1.Introduction -- 2.Leukocyte Interactions with the Endothelium -- 3.Signaling Mechanism -- 4.Factors Favoring Transcellular Migration -- 5.Why Does Transcellular Migration Exist? -- 6.Conclusion -- Acknowledgments -- References -- 3.Evolution of the Humoral Response during HCV Infection: Theories on the Origin of Broadly Neutralizing Antibodies and Implications for Vaccine Design / Alain Lamarre -- 1.A Brief Overview of the Current State of the Hepatitis C Virus Pandemic -- 2.Viral Immunopathogenesis -- 3.Vaccine-Trials: A Brief Overview -- 4.The Humoral Immune Response -- 5.Hypotheses on the Origin of bNt Abs and Implications for Vaccine Design -- References -- 4.Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control / Ameya Champhekar -- 1.Introduction: T-Cell Identity and Processing of T-Cell Progenitors -- 2.Transcriptional Dynamics of the T-Cell Program -- 3.Dynamic Transcription Factor Expression -- 4.Commitment: Transfer of Lineage Fidelity from Environment to Intrinsic Factors -- 5.From Transcription Factors to Developmental Process: Glimpses of Regulatory Circuitry -- 6.Conclusions: T-Cell Development as an Emergent Process -- Acknowledgments -- References -- 5.Gene Map of the HLA Region, Graves' Disease and Hashimoto Thyroiditis, and Hematopoietic Stem Cell Transplantation / Yasuo Morishima -- 1.Overview of HLA Genes, Autoimmune Thyroid Diseases, and Hematopoietic Stem Cell Transplantation -- 2.Gene Map of the HLA Region -- 3.Graves' Disease and Hashimoto Thyroiditis -- 4.HLA and Unrelated Donor Hematopoietic Stem Cell Transplantation -- 5.Perspectives -- Acknowledgments -- References -- 6.The Pathogenesis and Immunobiology of Mousepox / Luis J. Sigal -- 1.The Ectromelia Virus Model -- 2.Inherent Resistance to Mousepox -- 3.Acquired Resistance to Mousepox -- 4.Concluding Remarks -- References -- 7.MAP4K Family Kinases in Immunity and Inflammation / Tse-Hua Tan -- 1.Overview of MAP4K Family Kinases -- 2.MAP4K1 (HPK1) -- 3.MAP4K2 (GCK) -- 4.MAP4K3 (GLK) -- 5.MAP4K4 (HGK) -- 6.MAP4K5 (KHS, GCKR) -- 7.MAP4K6 (MINK) -- 8.Perspectives -- Acknowledgments -- References.
- Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.
- 9780128052150 (electronic bk.)
0128052155 (electronic bk.)
9780128047989 (electronic bk.)
0128047984 (electronic bk.)
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