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The Relationship Between PTFE Graft Ultrastructure and Cellular Ingrowth : The Influence of an Autologous Jugular Vein Wrap / H. Holubec, GC. Hunter, M. Chvapil, TA. Chvapil, VM. Bernhard, RL. Misiorowski, CW. Putnam

Conference Author
Biomaterials' Mechanical Properties (1992 : Pittsburgh, PA)
Physical Description
1 online resource (12 pages) : illustrations, figures, tables
Additional Creators
Bernhard, VM., Chvapil, M., Chvapil, TA., Holubec, H., Hunter, GC., Misiorowski, RL., Putnam, CW., American Society for Testing and Materials, and ASTM International
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Summary
Here, we report the differential effects on cellular ingrowth and healing caused by varying the mternodal distance (IND) of polytetrafluoroethylene (PTFE) grafts. In addition, we examined whether cellular ingrowth could be enhanced by an additional source of endothelial cells. Both carotid arteries of greyhound dogs were replaced with 5-cm lengths of 4-mm-diameter PTFE grafts of varying IND (30, 40, 60 ?m). The histologic characteristics of anastomotic and midgraft segments of grafts wrapped with autologous vein graft as a source of endothehal cells were compared to the contralateral unwrapped graft of identical IND. At five weeks the grafts were excised and examined histologically and the in vivo IND, cellular and microvessel ingrowth, and endothelialization of the luminal surface quantitated. All 30 ?m grafts (N = 8) were occluded by anastomotic pannus ingrowth (PI). The anastomoses of 40 and 60 ?m grafts were characterized by either intimal hyperplasia (IH) (N = 10) or healing with minimal intimal thickening (H) (N = 4). The mean reduction in IND at anastomoses was 68 to 75% for all grafts whereas midgraft IND was unaffected. The mean IND at anastomoses with PI was 7.0 ¿̐ư 1.5 ?m, IH 12.0 ¿̐ư 2.5 ?m, and 19.0 ¿̐ư 2.0 ?m for healed anastomoses. Midgraft cellular ingrowth was greater than that observed near anastomoses and varied with IND. The application of a vein wrap enhanced cellular and microvessel ingrowth and endothelialization of 40 and 60 ?m grafts. These data suggest that alterations in PTFE ultrastructure likely resulting from surgical manipulation during implantation may adversely influence anastomotic healing.
Dates of Publication and/or Sequential Designation
Volume 1994, Issue 1173 (January 1994)
Subject(s)
Other Subject(s)
ISBN
0803118945
9780803118942
9780803152618 (e-ISBN)
Digital File Characteristics
text file PDF
Bibliography Note
Includes bibliographical references 26.
Other Forms
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Also available online via the World Wide Web. Tables of contents and abstracts freely available; full-text articles available by subscription.
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Reproduction Note
Electronic reproduction. W. Conshohocken, Pa. : ASTM International, 1994. Mode of access: World Wide Web. System requirements: Web browser. Access may be restricted to users at subscribing institutions.
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Mode of access: World Wide Web.
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ASTM International PDF Purchase price USD25.
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