Distribution of Titanium and Vanadium Salts and Corrosion Products in Cells, Fluids, and Organs in vivo and in Cell Culture in vitro / K. Merritt, SA. Brown
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- Medical Applications of Titanium and Its Alloys: The Material and Biological Issues (1994 : Phoenix, Arizona)
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- 1 online resource (11 pages) : illustrations, figures, tables
- Additional Creators:
- Brown, SA., Merritt, K., American Society for Testing and Materials, and ASTM International
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- Machine generated contents note: Titanium Alloys as Implant Materials / M. A. Imam / A. C. Fraker -- Manufacturing Processes for Semi-Finished Titanium Biomedical Alloys / R. M. Forbes Jones / R. M. Davis -- Taguchi Experiment on the Mechanical Properties of Sintered Titanium 6-4 / R. R. Peterson / C. V. French -- New Titanium Alloys to be Considered for Medical Implants / T. Tateishi / Y. Ito / Y. Okazaki / A. Ito -- Characterization of Ti-15Mo Beta Titanium Alloy for Orthopaedic Implant Applications / J. A. Disegi / L. D. Zardiackas / D. W. Mitchell -- Microstructure and Properties of a New Beta Titanium Alloy, Ti-12Mo-6Zr-2Fe, Developed for Surgical Implants / J. H. Dumbleton / L. J. Gustavson / K. K. Wang -- Optimization of Properties of Ti-15Mo-2.8Nb-3A1-0.2Si and Ti-15Mo-2.8Nb-0.2Si-0.260 Beta Titanium Alloys for Application in Prosthetic Implants / S. K. Bhambri / R. H. Shetty / L. N. Gilbertson -- Mechanical and Tribological Properties and Biocompatibility of Diffusion Hardened Ti-13Nb-13Zr - A New Titanium Alloy for Surgical Implants / T. J. Fitzgerald / P. Kovacs / R. A. Poggie / J. A. Davidson / A. K. Mishra -- Methods of Detecting and Predicting Microfractures in Titanium / P. Ducheyne / J. Awerbuch / C. C. Ko / S. J. Hollister / D. Snoeyink / D. H. Kohn -- Evaluation of the Corrosion Fatigue Behavior of Porous Coated Ti-6Al-4V / H. Hampel / H. R. Piehler -- A Novel Porous Coating Geometry to Improve the Fatigue Strength of Ti-6Al-4V Implant Alloy / D. Wolfarth / P. Ducheyne -- Chemical and Electrochemical Aspects of the Biocompatibility of Titanium and Its Alloys / P. Kovacs / J. A. Davidson -- Passive Dissolution of Titanium in Biological Environments / P. Ducheyne / K. E. Healy -- Corrosion Behavior of Dental Casting Alloys Coupled with Titanium / J. Boyd / A. A. Chohayeb / F. C. Eichmiller / R. M. Waterstrat / A. C. Fraker -- Titanium Oxide Film Fracture and Repassivation: The Effect of Potential, pH, and Aeration / J. L. Gilbert / C. A. Buckley / E. P. Lautenschlager -- Transitional Behavior in Ti-6Al-4V Fretting Corrosion / P. Ducheyne / B. J. Smith -- Effects of Material Combination, Surface Treatment, and Environment of Fretting Corrosion of Ti-6Al-4V / S. A. Brown / K. Merritt / J. H. Payer / J. S. Kawalec / A. C. Montague -- Mechanical and Corrosion Properties of Nitrogen Diffusion Hardened Ti-6Al-4V Alloy / R. H. Shetty -- Characterizing the Fretting Fatigue Behavior of Ti-6Al-4V in Modular Joints / V. Chandrasekaran / D. W. Hoeppner -- Wear of Titanium 6-4 Alloy in Laboratory Tests and in Retrieved Human Joint Replacements / H. A. McKellop / T. Rostlund / F. Ebramzadeh / A. Sarmiento -- The In Vitro Response to Particulate Titanium Alloy / D. R. Haynes / D. W. Howie / S. D. Rogers / M. J. Pearcy -- Response of Titanium Surfaces to Simulated Biological Environments / C. W. Prince / L. C. Lucas / J. I. Ong -- In Vitro Osteoblast Responses to cpTi and Ti-6Al-4V Alloy / J. P. Wightman / R. A. Draughn / C. M. Stanford / J. C. Keller -- Induction of Bone Resorbing Agents by Titanium Particulates: Responses of Macrophages, Fibroblasts and Osteoblasts In Vitro / T. T. Glant / J. Yau / J. J. Jacobs -- Determination of In Vivo Titanium Release from a Non-Articulating Commercially Pure Titanium Implant / P. D. Bianco / P. Ducheyne / J. M. Cuckler -- Distribution of Titanium and Vanadium Salts and Corrosion Products in Cells, Fluids, and Organs in vivo and In Cell Culture in vitro / K. Merritt / S. A. Brown -- Clinical Studies on Titanium and Stainless Steel Plates (LC-DCP). A Comparative Evaluation / B. Rahn / S. M. Perren / O. E. M. Pohler / A. Ungersbock / F. W. Baumgart -- Wear and Osteolysis in Relation to Prostheses Design and Materials / M. A. McGee / D. W. Howie -- A 3-Year Prospective Study of Serum Titanium Levels in Patients with Primary Total Hip Replacements / J. Black / A. K. Skipor / J. J. Jacobs / L. M. Patterson / J. O. Galante / W. P. Paprosky -- Retrieval Analysis of Ti-6Al-4V Miller-Galante Total Knee Replacements / S. A. Brown / K. Merritt / M. J. Kraay / V. M. Goldberg.
- Studies were undertaken to determine the distribution, elimination and storage of titanium and vanadium in organs and in cells. Animals (hamsters) received injections of salts of titanium and vanadium and the distribution in blood, urine, and organs was determined. At the highest doses used (600 ug total of each element) titanium could be detected just above control levels in liver, spleen, kidney, and plasma. Vanadium was rapidly excreted but could be detected just above control levels in liver, spleen, urine, and plasma. Both elements were detected in bone (femur). Studies using fretting corrosion in hamsters indicated that most of the titanium remained at the site of deposition. There was some transport to the urine and plasma and also to bone. Most of the vanadium administered can be accounted for in rapid excretion in the urine. Most of the titanium remained at the site of deposition and little was transported from the site. The in vitro studies in cell culture confirmed the cell association (and thus retention) of titanium and the lack of cell association (and thus elimination) of vanadium. The highest dose of 600¿̐u750 ug of the element administered to the hamster is below the level of body burden of titanium found in tissues from patients with revision of total joints, and thus it can be expected that transport and organ deposition of titanium would occur in the humans at low levels. However, in general, the wear debris remains at the local site without evoking much of a biological response.
- Dates of Publication and/or Sequential Designation:
- Volume 1996, Issue 1272 (January 1996)
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- Includes bibliographical references 18.
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