Localization and Sex Steroid Regulation of Brain Aromatase Activity : Identification of a Positive Feedback Mechanism that may be Triggered by Environmental Cues / AC. Melo, JSG Edmunds, JS. Ramsdell
- Conference Author:
- Environmental Toxicology and Risk Assessment: Standardization of Biomarkers for Endocrine Disruption and Environmental Assessment: 8th Volume (8th : 1998 : Atlanta, GA)
- Physical Description:
- 1 online resource (13 pages) : illustrations, figures, tables
- Additional Creators:
- Edmunds, JSG, Melo, AC., Ramsdell, JS., American Society for Testing and Materials, and ASTM International
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- We performed assays for aromatase activity in serial 200 ?m sections of the three orthogonal planes of the brain and produced a three dimensional reconstruction of aromatase levels in Medaka (Oryzias latipes) brain. The regulation of this brain aromatase activity by sex steroids was then examined by in vivo exposure bioassays. We demonstrate that the activity of brain aromatase is localized to an area that contains the hypothalamus, a region of the brain involved in the regulation of the reproductive function. The exposure of Medaka to estradiol lead to increased brain aromatase levels; whereas, exposure to methyl-testosterone lead to decreased brain aromatase levels. The regulation of brain aromatase levels by both product and substrate may provide a sensitive trigger for environmental cues to alter sex behavior.
- Dates of Publication and/or Sequential Designation:
- Volume 1999, Issue 1364 (January 1999)
- Other Subject(s):
- 9780803154087 (e-ISBN)
- Digital File Characteristics:
- text file PDF
- Bibliography Note:
- Includes bibliographical references 26.
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- Also available online via the World Wide Web. Tables of contents and abstracts freely available; full-text articles available by subscription.
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- Electronic reproduction. W. Conshohocken, Pa. : ASTM International, 1999. Mode of access: World Wide Web. System requirements: Web browser. Access may be restricted to users at subscribing institutions.
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- Mode of access: World Wide Web.
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- ASTM International PDF Purchase price USD25.
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