Actions for Air Pollution Exposure Studies in Smokers and People with Chronic Obstructive Pulmonary Disease

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Air Pollution Exposure Studies in Smokers and People with Chronic Obstructive Pulmonary Disease / WS. Linn, JD. Hackney

Conference Author
Inhalation Toxicology of Air Pollution: Clinical Research Considerations (1983 : Philadelphia, PA)
Published
West Conshohocken, Pa. : ASTM International, 1985.
Physical Description
1 online resource (8 pages) : illustrations, figures, tables
Additional Creators
Linn, WS., Hackney, JD., American Society for Testing and Materials, and ASTM International
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Summary
People with chronic obstructive pulmonary disease (COPD) are often thought to be especially at risk from air pollution and thus are prime candidates for clinical exposure studies. However, scientific, ethical, legal, and practical problems must be faced in studying individuals with COPD. To deal with these problems, the following priorities of concern are suggested: (1) the safety and welfare of subjects, (2) scientific rigor of the experiment, (3) relevance of the experimental results to ¿̐ưreal-world¿̐ư health concerns, that is, to air quality regulatory decisions, and (4) improved general understanding of physiology or toxicology. Smoking often complicates interpretation of the results of clinical exposure studies; in many cases, smokers should be excluded to maximize scientific rigor. However, smokers may be viewed as a group with early or mild COPD: most have at least slight chronic bronchitis. Thus, in some investigations, smokers might be appropriate surrogates for diseased population groups. Care should be taken to distinguish between the effects of the experimental pollutant and the effects of recent smoking on smokers' experimental responses. Only a few of many potential ambient-air hazards have been investigated in people with COPD; no clear differences in responses from healthy people have been found. Only a few studies have attempted rigorous comparisons between smoking and nonsmoking subjects, either healthy or with lung disease. Their results have been inconclusive.
Dates of Publication and/or Sequential Designation
Volume 1985, Issue 872 (January 1985)
Subject(s)
Other Subject(s)
ISBN
9780803149373 (e-ISBN)
9780803104068
0803104065
Digital File Characteristics
text file PDF
Bibliography Note
Includes bibliographical references 13.
Other Forms
Also available online via the World Wide Web. Tables of contents and abstracts freely available; full-text articles available by subscription.
Full text article also available for purchase.
Also available in PDF edition.
Reproduction Note
Electronic reproduction. W. Conshohocken, Pa. : ASTM International, 1985. Mode of access: World Wide Web. System requirements: Web browser. Access may be restricted to users at subscribing institutions.
Technical Details
Mode of access: World Wide Web.
Source of Acquisition
ASTM International PDF Purchase price USD25.
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