The science of marijuana / Les Iversen
- Author:
- Iversen, Leslie L.
- Published:
- New York, NY : Oxford University Press, 2018.
- Edition:
- 3rd edition.
- Physical Description:
- 1 online resource : illustrations (black and white).
- Access Online:
- ezaccess.libraries.psu.edu
- Series:
- Oxford scholarship online
- Contents:
- Machine generated contents note: 1.History and the Plant -- A Brief History -- Twenty-First-Century Revival of Cannabis -- The Plant -- Cannabis Preparations -- Cannabis and Hemp -- 2.The Pharmacology of Delta-9-Tetrahydrocannabinol (THC) -- Discovery of THC -- Other Phytocannabinoids -- Synthetic Cannabinoids -- Cannabinoid Antagonists -- CB-2 Selective Agonists -- How Does THC Get to the Brain? -- Smoking -- Vaping -- Dabbing -- Oral Absorption -- Other Routes of Administration -- Elimination of THC from the Body -- How Does THC Work? -- Discovery of Cannabinoid Receptors -- Neuroanatomical Distribution of CB-1 and CB-2 Receptors in Brain and Peripheral Tissues -- 3.Peripheral and Central Effects of THC -- Inhibition of Neurotransmitter Release -- Effects on the Heart and Blood Vessels -- Effects on Pain Sensitivity -- Effects on Motility and Posture -- The Billy Martin Tetrad -- Laboratory Studies of Cannabinoids in Human Volunteers -- Effects on Learning and Memory -- Subjective Reports of the Marijuana High -- Subjective Effects of Synthetic Cannabinoids -- Comparisons of Marijuana with Alcohol -- What Can Animal Behavior Experiments Tell Us? -- Discriminative Stimulus Effects -- Effects on Cognition -- Anti-Anxiety Effects -- 4.Endocannabinoids -- Discovery -- Biosynthesis and Inactivation of Endocannabinoids -- Physiological Functions of Endocannabinoids -- Retrograde Signaling Molecules at Synapses -- Control of Energy Metabolism and Body Weight -- Regulation of Pain Sensitivity -- Cardiovascular Control -- Other Functions -- Development of a New Endocannabinoid-Based Pharmacology -- Novel Cannabinoid Receptor Agonists or Antagonists -- Inhibitors of Endocannabinoid Inactivation -- 5.Medical Uses of Marijuana---Fact or Fantasy? -- Historical -- The Modern Revival of Interest in Cannabis-Based Medicines -- Introduction -- The United States -- Europe -- Other Countries -- Medicinal Cannabis -- Fully Licensed Cannabinoids -- Medical Indications for Cannabis -- Is There Any Role for Smoked Marijuana as a Medicine? -- Cannabinoid Antagonist for the Treatment of Obesity -- Placebo Effects -- Summary -- The Supply of Cannabis to "Cannabis Pharmacies" -- The Dutch Model -- Canada -- The United States -- Conclusion -- 6.Is Cannabis Safe? -- Safety Studies in Laboratory Animals -- Cannabis-Related Deaths -- Acute Effects of Cannabis -- Can Cannabis Use Lead to Psychosis? -- Effects of Cannabis on Motivation -- Effects of Cannabis on Driving -- Are There Persistent Cognitive Deficits? -- Vulnerability of the Teenage Brain -- Tolerance and Dependence -- How Likely Are Recreational Cannabis Users to Develop Cannabis Use Disorder? -- Is Cannabis a "Gateway Drug"? -- Adverse Effects on Fertility and the Unborn Child -- Special Hazards of Smoked Marijuana -- Summary -- 7.The Recreational Use of Cannabis -- Prevalence -- How Is Cannabis Consumed and Where Does It Come From? -- Countries or States That Have "Legalized" Cannabis -- The Netherlands -- Portugal -- Uruguay -- The United States -- Canada -- Snapshots of Cannabis Use Outside Europe -- Conclusion -- 8.Where Are We and Where Are We Going? -- The Case for Medical Marijuana, and Some Cautions -- The Case for Allowing Cannabis for Recreational Use -- Future Scenarios -- Positive -- Negative -- Conclusion.
- Summary:
- Marijuana (cannabis) is the most widely used recreational drug after nicotine and alcohol. This text reviews the rapidly growing body of scientific evidence on cannabis - how it works, the role of endogenous cannabinoids in the brain and body, and the opportunities for new medicines based on such knowledge. The regulation of cannabis use varies considerably throughout the world. This work reviews the rapid changes that have occurred in liberalizing the medical use of cannabis, and in some instances the full legalization of cannabis use, with an emphasis on events in the United States and Canada. The advantages and disadvantages of liberalizing the medical and recreational use of cannabis are discussed in a neutral manner, leaving the reader to decide.
- Subject(s):
- ISBN:
- 9780190846879 (ebook)
- Audience Notes:
- Specialized.
- Bibliography Note:
- Includes bibliographical references and index.
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